Sequential acquisition of human papillomavirus (HPV) infection of the anus and cervix: the Hawaii HPV Cohort Study.
Sequential acquisition of human papillomavirus (HPV) infection of the anus and cervix: the Hawaii HPV Cohort Study.
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DOI：
10.1086/651620
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发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Hernandez BY
中科院分区：
文献类型：
--
作者：
Goodman MT;Shvetsov YB;McDuffie K;Wilkens LR;Zhu X;Thompson PJ;Ning L;Killeen J;Kamemoto L;Hernandez BY
关于健康女性肛门HPV感染的流行病学及其与宫颈HPV感染的关系，我们知之甚少。通过对751名性活跃女性的纵向队列研究，研究了偶发性宫颈（或肛门）HPV感染与随后发生基因型一致的偶发性肛门（或宫颈）HPV感染风险的关系。使用考克斯回归获得的经t检验调整的风险比作为相对风险（RR）的测量。与先前没有肛门/宫颈HPV感染且基因型一致的女性相比，在具有相同基因型的宫颈HPV感染后获得肛门HPV感染的RR为20.5（95%CI：16.3-25.7）;在具有相同基因型的肛门HPV感染后获得宫颈HPV感染的RR为8.8（95%CI：6.4-12.2）。RR因系统发育物种而异，在先前在子宫颈感染同种型的妇女中，α3/α15和α1/α8/α10型感染肛门的可能性大于其他类型。肛门和宫颈HPV感染连续发生似乎很常见。高度的基因型特异性一致性表明，宫颈（阴道）和肛门可能作为其他解剖部位HPV感染的储存库。
Relatively little is known about the epidemiology of anal HPV infection among healthy women and its relation to cervical HPV infection. The association of an incident cervical (or anal) HPV infection with the subsequent risk of a genotype-concordant incident anal (or cervical) HPV infection was examined through a longitudinal cohort study of 751sexually-active women. Age-adjusted hazard ratios, obtained using Cox regression, served as measures of relative risk (RR). The RR of acquiring an anal HPV infection after a cervical HPV infection with the same genotype was 20.5 (95% CI: 16.3-25.7); and the RR of acquiring a cervical HPV infection following an anal HPV infection with the same genotype was 8.8 (95% CI: 6.4-12.2) compared to women without a preceding anal/cervical HPV infection with a concordant genotype. RRs varied by phylogenetic species, with α3/α15 and α1/α8/α10 types having a greater likelihood than other types of infecting the anus among women with a preceding same-type infection at the cervix. It appears common for anal and cervical HPV infections to occur consecutively. The high degree of genotype-specific concordance suggests that the cervix (vagina) and anus may serve as reservoirs for HPV infection at the other anatomic site.
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影响因子：
11.2
作者：
Goodman MT;Shvetsov YB;McDuffie K;Wilkens LR;Zhu X;Thompson PJ;Ning L;Killeen J;Kamemoto L;Hernandez BY
通讯作者：
Hernandez BY
影响因子：
39.2
作者：
Piketty, C;Darragh, TM;Palefsky, JM
通讯作者：
Palefsky, JM
影响因子：
9.4
作者：
Gravitt, PE;Peyton, CL;Wheeler, CM
通讯作者：
Wheeler, CM
影响因子：
11.2
作者：
Castle, PE;Jeronimo, J;Burk, RD
通讯作者：
Burk, RD
影响因子：
5
作者：
MICKEY, RM;GREENLAND, S
通讯作者：
GREENLAND, S