Hair cortisol and cortisone are decreased by natural sunlight
Hair cortisol and cortisone are decreased by natural sunlight
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DOI：
10.1016/j.psyneuen.2016.06.016
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发表时间：
2016-10-01
影响因子：
3.7
通讯作者：
van Rossum, Elisabeth F. C.
中科院分区：
文献类型：
--
作者：
Wester, Vincent L.;van der Wulp, Nils R. P.;van Rossum, Elisabeth F. C.
背景和目标：头发糖皮质激素（皮质醇和可的松）越来越多地被用作长期综合暴露于糖皮质激素的措施。糖皮质激素逐渐从毛干中消失，这可能是由于暴露于自然阳光中的紫外线（UV）辐射。本研究旨在探讨日光照射对头发糖皮质激素的影响。材料与方法：取9名志愿者的头发标本，用免疫组织化学方法检测头发中糖皮质激素的含量（中位年龄33 [范围21-81]，7名女性），每个头发样品的一部分暴露于三种实验条件：重复暴露于自然阳光40小时（自然UV），暴露于大量人工UV辐射，并在黑暗中储存（对照）。结果：与对照组相比，自然日光照射（中位数降低-3.1pg/mg或-54%，P < 0.001）和人工紫外线照射（中位数降低-4.7pg/mg或-75%，P = 0.003）后，9份头发中的HairF降低。9个样本中有8个在自然阳光照射后头发E下降（-7.6 pg/mg或-32%，P = 0.012）和人工UV（-10.7 pg/mg或52%，P = 0.026）。暴露在自然阳光下会降低头皮毛发中的糖皮质激素含量，这显然是通过紫外线辐射，因此，在涉及毛发糖皮质激素测量的研究中应考虑到这是一个重要的混杂因素。(C)2016爱思唯尔有限公司版权所有
Background and aims: Hair glucocorticoids (cortisol and cortisone) are increasingly used as measures of long-term integrated exposure to glucocorticoid hormones. Glucocorticoids gradually disappear from the hair shaft, which may result from exposure to ultraviolet (UV) radiation in natural sunlight. We aimed to study the influence of sun exposure on hair glucocorticoids.Material and methods: Scalp hair samples were obtained from nine volunteers (median age 33 [range 21-81], 7 females), and part of each hair sample was exposed to three experimental conditions: repeated exposure to natural sunlight for 40 h (natural UV), exposure to a high amount of artificial UV radiation, and storage in the dark (control). Hair cortisol (HairF) and cortisone (HairE) were quantified by liquid chromatography tandem mass spectrometry.Results: When compared to control, HairF was decreased in 9 out of 9 hair samples after natural sunlight exposure (median decrease -3.1 pg/mg or -54%, P < 0.001) and artificial UV radiation (-4.7 pg/mg or -75%, P = 0.003). HairE decreased in 8 out of 9 samples, both after natural sunlight (-7.6 pg/mg or -32%, P = 0.012) and artificial UV (-10.7 pg/mg or 52%, P = 0.026).Conclusions: Exposure to natural sunlight decreases the glucocorticoid content of scalp hair, apparently through UV radiation, and is therefore an important confounder that should be considered in studies involving the measurement of hair glucocorticoids. (C) 2016 Elsevier Ltd. All rights reserved.