Preterm birth: Inflammation, fetal injury and treatment strategies
Preterm birth: Inflammation, fetal injury and treatment strategies
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DOI：
10.1016/j.jri.2016.11.008
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发表时间：
2017-02-01
影响因子：
3.4
通讯作者：
Stock, Sarah J.
中科院分区：
文献类型：
--
作者：
Boyle, Ashley K.;Rinaldi, Sara F.;Stock, Sarah J.
早产 (PTB) 是 5 岁以下儿童死亡的主要原因，约占全球出生的 11%。早产儿面临许多健康并发症的风险，特别是脑瘫，还有呼吸系统和胃肠道疾病。早产可以是医学指征/选择性手术，也可以是自发发生。自发性 PTB 通常与宫内感染/炎症有关。子宫内炎症介质的存在与胎儿损伤有关，特别是影响胎儿的肺部和大脑。本综述将概述 (i) 炎症在足月和 PTB 中的作用，(ii) 感染/炎症对胎儿发育的影响，以及 (iii) 针对 PTB 的最新策略。迫切需要进一步研究开发预防和治疗 PTB 的有效方法，尤其是减少胎儿损伤。 (C) 2016 年作者。由 Elsevier Ireland Ltd 出版。这是一篇遵循 CC BY-NC-ND 许可证 (http://creativecommons.org/licenses/by-nc-nd/4.0/) 的开放获取文章。
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury. (C) 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).