Development of proton computed tomography detectors for applications in hadron therapy.
Development of proton computed tomography detectors for applications in hadron therapy.
复制标题
DOI：
10.1016/j.nima.2015.07.066
复制
发表时间：
2016-02-11
期刊：
影响因子：
--
通讯作者：
Schulte RW
中科院分区：
文献类型：
--
作者：
Bashkirov VA;Johnson RP;Sadrozinski HF;Schulte RW
使用质子和重离子的放射疗法是一种有吸引力的癌症治疗形式，可以增强目前难以治愈的癌症的局部控制和存活，并且由于保留正常组织而导致副作用较少。然而，粒子治疗面临着重大的技术挑战，因为人们无法使用现有成像技术提供的数据准确预测患者体内的粒子范围。质子计算机断层扫描（pCT）是一种新兴的成像方式，能够提高范围预测的准确性。在本文中，我们描述了我们小组设计和建造的连续pCT扫描仪，其目标是通过重建患者组织中相对于水的阻止能力的准确3D图来支持粒子治疗计划和图像引导。我们迄今为止建造的pCT扫描仪由硅望远镜和能量或范围探测器组成，硅望远镜在要重建的物体之前和之后跟踪质子，能量或范围探测器测量质子的剩余能量和/或范围，用于评估物体中每个质子的水等效路径长度（WEPL）。概述了pCT扫描仪及其校准的概念设计的十年之久的演变。扫描仪性能测试的结果，这表明，最新的pCT扫描仪的方法准备在强子治疗的临床应用。
Radiation therapy with protons and heavier ions is an attractive form of cancer treatment that could enhance local control and survival of cancers that are currently difficult to cure and lead to less side effects due to sparing of normal tissues. However, particle therapy faces a significant technical challenge because one cannot accurately predict the particle range in the patient using data provided by existing imaging technologies. Proton computed tomography (pCT) is an emerging imaging modality capable of improving the accuracy of range prediction. In this paper, we describe the successive pCT scanners designed and built by our group with the goal to support particle therapy treatment planning and image guidance by reconstructing an accurate 3D map of the stopping power relative to water in patient tissues. The pCT scanners we have built to date consist of silicon telescopes, which track the proton before and after the object to be reconstructed, and an energy or range detector, which measures the residual energy and/or range of the protons used to evaluate the water equivalent path length (WEPL) of each proton in the object. An overview of a decade-long evolution of the conceptual design of pCT scanners and their calibration is given. Results of scanner performance tests are presented, which demonstrate that the latest pCT scanner approaches readiness for clinical applications in hadron therapy.