Bioactive phenolics and polar compounds from Melilotus messanensis
Bioactive phenolics and polar compounds from Melilotus messanensis
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DOI：
10.1016/s0031-9422(98)00453-1
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发表时间：
1999-01-01
期刊：
影响因子：
3.8
通讯作者：
Castellano, D
中科院分区：
文献类型：
--
作者：
Macías, FA;Simonet, AM;Castellano, D
从三叶草的甲醇提取物中分离得到新的香豆素A、3-芳基香豆素甲素B和2-芳基苯并呋喃丙醇C，经波谱方法鉴定。已知的异黄酮类化合物：芒柄花素和环素；异黄酮类残留内酯；黄酮类甘草素；(3R，4R)-胡萝卜素、3-羟基甲基香豆素和草木内酯B；香豆素、4‘-O-甲基香豆素和7-羟基-4’，5‘-二甲氧基香豆素；3-芳基香豆素3-(4’-methoxy-2‘-hydroxyphenyl)-7-hydroxycoumarin；木脂素松脂醇；3-羟基香豆素和简单酚类化合物p-香豆酸、香草酸、对羟基苯甲酸、1个二萜、2个内酯、1个环和2个皂苷。环菌素、香豆内酯、4‘-O-甲基香豆素、7-羟基-4’，5‘-二甲氧基香豆素、3-(4’-methoxy-2‘-hydroxyphenyl)-7-hydroxycoumarin和3-羟基香豆素为首次报道。研究了10(-4)-10(-9)M的12种酚类化合物、2种Loliolide、1种二萜类和1种环戊醇的系列水溶液对双子叶植物生菜萌发和生长的影响。对罗马、黑麦、番茄和单子叶植物洋葱、大麦进行了研究。已发现异黄酮类、芒柄花素和环素以及蕨类药用植物提取物主要抑制洋葱的萌发。(C)1998由爱思唯尔科学有限公司出版。版权所有。
The methanolic extract from sweetclover, Melilotus messanensis, afforded the new coumestan melimessanol A, the 3-arylcoumarin melimessanol B and the 2-arylbenzofuran melimessanol C, which where identified on the basis of spectroscopic methods. The known isoflavones formononetin and cyclosin; the isoflavanone vestitone; the flavanone liquiritigenin; the pterocarpans (3R,4R)-medicarpin, 3-hydroxymedicarpin and melilotocarpane B; the coumestans coumestrol, 4'-O-methylcoumestrol and 7-hydroxy-4',5'-dimethoxycoumestan; the 3-arylcoumarin 3-(4'-methoxy-2'-hydroxyphenyl)-7-hydroxycoumarin; the lignan pinoresinol; 3-hydroxycoumarin and the simple phenolics p-coumaric acid, vanillic acid, p-hydroxybenzoic acid, a diterpene, two loliolides, a cyclitol and two saponins have been also isolated and spectroscopically identified. Cyclosin, vestitone, 4'-O-methylcoumestrol, 7-hydroxy-4',5'-dimethoxycoumestan, 3-(4'-methoxy-2'-hydroxyphenyl)-7-hydroxycoumarin and 3-hydroxycoumarin are first reported in the genus Melilotus. The effects of a series of aqueous solutions from 10(-4)-10(-9) M of twelve phenolics, two loliolides, a diterpene and a cyclitol on germination and growth of the dicotyledons Lactuca sativa cvs. Roman and Nigra and Lycopersicum esculentum and the monocotyledons Allium cepa and Hordeum vulgare, have been studied. The isoflavones formononetin and cyclosin and the pterocarpan medicarpin have been found to inhibit principally A. cepa germination. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.