Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro
Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro
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DOI：
10.1093/jac/48.6.775
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发表时间：
2001-12-01
影响因子：
5.2
通讯作者：
Ledochowski, M
中科院分区：
文献类型：
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作者：
Lass-Flörl, C;Dierich, MP;Ledochowski, M
本研究研究了选择性5-羟色胺再摄取抑制剂（SSRI）对烟曲霉（n = 11）、黄曲霉（n = 9）、土曲霉（n = 10）和近平滑念珠菌（ATCC 22019）临床分离株的杀真菌活性。采用微量肉汤稀释法对常用药物氟西汀、舍曲林、帕罗西汀、瑞波西汀进行检测。此外，我们还研究了短期暴露于药物后是否会发生抗生素后效应。各种SSRIs显示出时间和剂量依赖性效应，并且对测试的生物体具有杀真菌作用。舍曲林和氟西汀是最活跃的药物，但有不同的敏感性测试的各种菌株。再生长的滞后取决于测试的各种SSRI及其浓度。舍曲林浓度低于或等于最低杀菌浓度处理4 h，则A.烟曲霉和A.黄的总之，我们的体外研究清楚地证明了SSRIs的抗真菌作用。需要动物研究来评估这些精神药物在真菌感染管理中的潜在作用。
This study investigated the fungicidal activity of selective serotonin reuptake inhibitors (SSRIs) against clinical isolates of Aspergillus fumigatus (n = 11), Aspergillus flavus (n = 9), Aspergillus terreus (n = 10) and Candida parapsilosis (ATCC 22019). The common drugs fluoxetine, seroxate, sertraline, paroxetine and reboxetine were applied in a broth microdilution test. In addition, we examined whether a post-antibiotic effect occurs following short exposure to the drugs. The various SSRIs showed time- and dose-dependent effects and were fungicidal towards the organisms tested. Sertraline and fluoxetine were the most active drugs, yet there were differences in the susceptibility of the various isolates tested. A lag of regrowth was dependent on the various SSRIs tested and their concentration. Treatment for 4 h at concentrations of sertraline below and equipotent to the minimal fungicidal concentration resulted in a lag of regrowth of 8-24 h for isolates of A. fumigatus and A. flavus. In conclusion, our in vitro studies clearly demonstrate antifungal effects of SSRIs. Animal studies are needed to evaluate the potential role of these psychotropic drugs in the management of fungal infections.