MESENCHYMAL STEM-CELLS
MESENCHYMAL STEM-CELLS
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DOI：
10.1002/jor.1100090504
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发表时间：
1991-09-01
影响因子：
2.8
通讯作者：
CAPLAN, AI
中科院分区：
文献类型：
--
作者：
CAPLAN, AI
胚胎中的骨和软骨形成以及成人中的修复和周转涉及少量称为间充质干细胞的细胞的后代。这些细胞分裂，并且它们的后代变成致力于特定的和独特的表型途径，具有离散步骤的谱系，并且最后是参与制造独特组织类型的终末期细胞，例如，软骨或骨。局部提示（外在因素）和基因组潜能（内在因素）在每个谱系步骤中相互作用，以控制新生组织中细胞的速率和特征表型。对这些间充质干细胞的研究，无论是从胚胎还是成年人中分离出来的，都为新的治疗技术的出现提供了基础。自体干细胞的分离、有丝分裂扩增和定点递送可以控制骨骼组织的快速和特异性修复。
Bone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end-stage cells involved with fabrication of a unique tissue type, e.g., cartilage or bone. Local cuing (extrinsic factors) and the genomic potential (intrinsic factors) interact at each lineage step to control the rate and characteristic phenotype of the cells in the emerging tissue. The study of these mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self-cell repair. The isolation, mitotic expansion, and site-directed delivery of autologous stem cells can govern the rapid and specific repair of skeletal tissues.