Sleep during concanavalin-A-induced hepatitis and peritonitis in inbred mice.
Sleep during concanavalin-A-induced hepatitis and peritonitis in inbred mice.
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近交小鼠在伴刀豆球蛋白 A 诱导的肝炎和腹膜炎期间的睡眠。
DOI：
10.1093/sleep/28.5.571
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发表时间：
2005
期刊：
影响因子：
5.6
通讯作者：
Rehg,JeroldE
中科院分区：
文献类型：
--
作者：
Toth,LindaA;Hughes,LarryF;Rehg,JeroldE
研究目标：评估刀豆蛋白 A 诱导的肝炎作为研究肝脏疾病与嗜睡改变之间关系的模型的适用性。设计：我们对经历刀豆蛋白 A 诱导炎症的各种近交系小鼠的睡眠模式进行了表征。地点：南伊利诺伊大学医学院，伊利诺伊州斯普林菲尔德。干预：静脉或腹膜内施用伴刀豆球蛋白-A。参与者：近交系小鼠。测量和结果：静脉内和腹膜内施用刀豆球蛋白-A 均会引起慢波睡眠的应变依赖性变化。 ConA 治疗还降低了自发运动活动。 ConA 引起的慢波睡眠变化随剂量、给药途径和给药昼夜节律而变化。与其他品系相比，C57BL/6J小鼠在ConA给药8小时后血清干扰素-γ浓度较低。结论：这些数据首次证明小鼠的肝脏炎症伴随睡眠增强和运动活动减少。
Study objectives: To assess the suitability of concanavalin-A-induced hepatitis as a model for investigating the relationships between hepatic disease and alterations in somnolence. Design: We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation. Setting: Southern Illinois University School of Medicine, Springfield, IL. Intervention: Intravenous or intraperitoneal administration of concanavalin-A.Participants: Inbred mice. Measurements and Results: Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slowwave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-γ at 8 hours after ConA administration. Conclusions: These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.