The distribution of immune cells in the uveal tract of the normal eye
The distribution of immune cells in the uveal tract of the normal eye
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DOI：
10.1038/eye.1997.49
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发表时间：
1997-01-01
期刊：
影响因子：
3.9
通讯作者：
McMenamin, PG
中科院分区：
文献类型：
--
作者：
McMenamin, PG
炎症性和免疫介导的眼部疾病并不纯粹是浸润性炎症细胞的结果，而是可以由通过正常眼睛驻留或运输的免疫细胞引发或传播。特别是葡萄膜是许多此类细胞的主要部位，包括驻留组织巨噬细胞、树突细胞和肥大细胞。本文综述了这些细胞和其他细胞在正常眼虹膜、睫状体和脉络膜中的分布和位置。葡萄膜含有丰富的巨噬细胞和MHC II类+树突状细胞网络。后者似乎位于战略位置，作为哨兵捕获和采样的血液和眼内抗原。大多数物种的脉络膜中存在大量肥大细胞，但在许多实验室动物的前葡萄膜中几乎不存在;然而，人类虹膜确实含有肥大细胞。在正常眼的葡萄膜中存在少量被认为是运输淋巴细胞的物质。关于嗜酸性粒细胞的存在或不存在的数据很少。这些不同类型的细胞在免疫稳态和眼部炎症中的作用被简要地考虑。
Inflammatory and immune-mediated diseases of the eye are not purely the consequence of infiltrating inflammatory cells but may be initiated or propagated by immune tells which are resident or trafficking through the normal eye. The uveal tract in particular is the major site of many such cells, including resident tissue macrophages, dendritic cells and mast cells. This review considers the distribution and location of these and other cells in the iris, ciliary body and choroid in the normal eye. The uveal tract contains rich networks of both resident macrophages and MHC class II+ dendritic cells. The latter appear strategically located to act as sentinels for capturing and sampling blood-borne and intraocular antigens. Large numbers of mast cells are present in the choroid of most species but are virtually absent from the anterior uvea in many laboratory animals; however, the human iris does contain mast cells. Small numbers of what are presumed to be trafficking lymphocytes are present in the uveal tract of normal eyes. There is little data available on the presence or absence of eosinophils. The role of these various cell types in immune homeostasis and ocular inflammation is briefly considered.