Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children
Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children
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DOI：
10.21307/pjm-2018-041
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Kapusniak, Janusz
中科院分区：
文献类型：
--
作者：
Barczynska, Renata;Litwin, Mieczyslaw;Kapusniak, Janusz
越来越多的超重和肥胖儿童构成了现代世界的一个主要健康问题，有人认为肠道微生物区系可能会影响从食物中摄取的能量。本研究的目的是测定肠道中类杆菌、普氏杆菌、梭状芽胞杆菌、乳杆菌和双歧杆菌在肠道中的数量和比例，并测定20名肥胖儿童和20名正常体重儿童粪便中短链脂肪酸(SCFAs)和支链脂肪酸(BCFAs)含量。肥胖儿童粪便微生物区系以梭状芽孢杆菌和乳杆菌为主，类杆菌(普氏杆菌和类杆菌)较少(p<；0.001)。肥胖儿童粪便中SCFAs浓度低于正常体重儿(p=0.04)。然而，与瘦孩子相比，这些差异只在肥胖儿童中显著，而在超重儿童中并不显著。因此，在我们的研究中，肥胖与肠道生物失调和以飞鼠门为优势的肠道有关。其次，肥胖儿童的粪便中SCFAs含量较低。
The growing number of children with overweight and obesity constitutes a major health problem of the modern world and it has been suggested that intestinal microbiota may influence energy intake from food. The objectives of this study were to determine quantity and proportions of dominant genera of Bacteroides, Prevotella (phylum Bacteroidetes); Clostridium, Lactobacillus (phylum Firmicutes) and Bifidabacterium (phylum Actinobacteria) in the intestines and to determine the content of short-chain fatty acids (SCFAs) and branched-chain fatty acids (BCFAs) in the stool of 20 obese children and 20 children with normal body weight. Strains classified as Firmicutes (Clostridium and Lactobacillus) predominated in stool microbiota of obese children, while those of Bacteroidetes (Prevotella and Bacteroides) were in minority (p < 0.001). Concentration of SCFAs in the stool of obese children was lower in comparison to the stool of normal weight children (p = 0.04). However, these differences were significant only in obese children, not in overweight children in comparison with the lean ones. Therefore, in our study obesity was associated with intestinal dysbiosis and a predominance of phylum Firmicutes. Secondly, stool of obese children contained lower amounts of SCFAs.