GASTRIC-EMPTYING AND GASTROINTESTINAL ABSORPTION OF ALCOHOL INGESTED WITH A MEAL
GASTRIC-EMPTYING AND GASTROINTESTINAL ABSORPTION OF ALCOHOL INGESTED WITH A MEAL
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DOI：
10.1007/bf01311667
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发表时间：
1986-04-01
影响因子：
3.1
通讯作者：
MODIGLIANI, R
中科院分区：
文献类型：
--
作者：
CORTOT, A;JOBIN, G;MODIGLIANI, R
我们测量了，通过插管法，胃排空和胃肠道吸收的酒精摄入一餐在7个健康的非酒精受试者。含[14 C]PEG和乙醇（1 g/kg体重）的均质化膳食经胃内给药，同时将含[57 CO]维生素B12的生理盐水灌注到十二指肠中。在摄入的酒精中，39.4 .+-. 4.1%在餐后第一个小时内通过胃壁吸收，73.2 ± 0.5%在餐后第二个小时内通过胃壁吸收。4.2%，而仅24 . 3%在十二指肠中同时吸收。因此，随餐摄入的酒精主要在胃中快速吸收; Treitz角以下的小肠对酒精吸收的贡献可以忽略不计。
We have measured, by an intubation method, gastric evacuation and gastrointestinal absorption of alcohol ingested with a meal in seven healthy nonalcoholic subjects. A homogenized meal containing [14C]PEG and ethanol (1 g/kg body wt) was given intragastrically while saline containing [57CO]vitamin B12 was perfused into the duodenum. Of the ingested alcohol, 39.4 .+-. 4.1% was absorbed through the stomach wall during the first postprandial hour and 73.2 .+-. 4.2% during the total postcibal period, whereas only 24 .+-. 3% was absorbed during the same time in the duodenum. Thus alcohol ingested with a meal is mainly and rapidly absorbed in the stomach; the contribution of the small intestine below the angle of Treitz to alcohol absorption is negligible.