Dietary omega-3 polyunsaturated fatty acid intake is related to a protective high-density lipoprotein subspecies profile independent of genetic effects: A monozygotic twin pair study
Dietary omega-3 polyunsaturated fatty acid intake is related to a protective high-density lipoprotein subspecies profile independent of genetic effects: A monozygotic twin pair study
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DOI：
10.1016/j.atherosclerosis.2011.09.010
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发表时间：
2011-12-01
期刊：
影响因子：
5.3
通讯作者：
Pietilainen, Kirsi H.
中科院分区：
文献类型：
--
作者：
Bogl, Leonie H.;Maranghi, Marianna;Pietilainen, Kirsi H.
背景：关于饮食和高密度脂蛋白亚型分布的研究有限。目的：通过对同卵双生子(MZ)的研究，探讨不受遗传影响的常量营养素组成与脂蛋白颗粒大小和高密度脂蛋白亚型的关系。方法：从两个纵向人群研究(FinnTwin16和FinnTwin12)中鉴定出24对年龄在23-33岁的健康MZ双胞胎。总能量和营养素的摄入量用3天的食物记录来评估，体力活动用贝克指数来衡量。非变性梯度凝胶电泳法测定细胞内高密度脂蛋白亚型分布。结果：在男性(β+/-SE：1.00+/-0.26 nm，p=0.004)和女性(β+/-SE：0.90+/-0.21 nm，p=0.001)中，用来自omega-3多不饱和脂肪酸(n-3PUFA)的一个能量百分比取代来自其他类型脂肪的能量与高密度脂蛋白亚种2b、3a和3b的相对比例的变化有关。在利用MZ双生子(β+/-SE：0.37+/-0.14 nm，p=0.019)测量的对内差异来控制遗传和共享环境影响的分析中，这种关联仍然显著。与低摄入量的同卵双胞胎相比，n-3PUFA摄入量高的双胞胎HDL2b大颗粒的比例显著增加，而小尺寸HDL3a和HDL3b的比例低(p<；0.05)。结论：我们的数据表明，n-3PUFA摄入量与HDL2b大颗粒分布的有利变化有关，而不受遗传因素和共同环境因素的影响。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Studies on diet and high-density lipoprotein (HDL) subspecies distribution are limited. Objective: We examined the relationship between macronutrient composition and lipoprotein particle size and HDL subspecies independent of genetic effects by studying monozygotic (MZ) twins.Methods: 24 healthy MZ twin pairs aged 23-33 years were identified from two longitudinal population-based studies, FinnTwin16 and FinnTwin12. Total energy and nutrient intake were assessed with 3-day food records and physical activity was measured by the Baecke index. HDL subspecies distribution was determined by non-denaturing gradient gel electrophoresis. Associations between diet composition and HDL mean particle size were determined by multivariate nutrient density models adjusted for confounding variables.Results: Substituting one energy percentage from omega-3 polyunsaturated fatty acids (n-3 PUFAs) for a corresponding amount of energy from other type of fats was related to changes in the relative proportions of the HDL subspecies 2b, 3a and 3b toward a larger mean particle size in men (beta +/- SE: 1.00 +/- 0.26 nm, p = 0.004) and women (beta +/- SE: 0.90 +/- 0.21 nm, p = 0.001). This association remained significant in analyses controlling for genetic and shared environmental influences using within-pair differences of the measures in MZ twin pairs (beta +/- SE: 0.37 +/- 0.14 nm, p = 0.019). Twins with the higher n-3 PUFA intake had significantly higher proportions of large HDL2b particles and lower proportions of smaller-sized HDL3a and HDL3b particles as compared to their co-twins with lower intakes (p < 0.05).Conclusions: Our data suggest that n-3 PUFA intake is associated with a favorable change in the distribution of HDL subspecies towards larger particles independent of genetic and shared environmental factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.