High-yielding intramolecular direct arylation reactions with aryl chlorides
High-yielding intramolecular direct arylation reactions with aryl chlorides
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DOI：
10.1021/ol050501v
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发表时间：
2005-04-28
期刊：
影响因子：
5.2
通讯作者：
Fagnou, K
中科院分区：
文献类型：
--
作者：
Campeau, LC;Thansandote, P;Fagnou, K
N-杂环卡宾-钯催化剂体系用于促进广泛的芳基氯化物的直接芳基化反应，以形成六元环和五元环联芳基。揭示了卤化物对钯催化剂活性的影响，以及NHC盐的有利作用，只需在反应混合物中加入咪唑盐就可以增加催化剂的转化率。
An N-heterocyclic carbene palladium catalyst system is used to promote direct arylation of a broad range of aryl chlorides to form six- and five-membered ring biaryls. An influence of the halide on the palladium precatalyst on catalyst activation has been revealed, as has a beneficial effect of NHC salts that allows the turnover numbers to be increased by simple addition of imidazolium salts to the reaction mixture.