Emotional context modulates response inhibition: Neural and behavioral data
Emotional context modulates response inhibition: Neural and behavioral data
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DOI：
10.1016/j.neuroimage.2009.08.045
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Carretie, Luis
中科院分区：
文献类型：
--
作者：
Albert, Jacobo;Lopez-Martin, Sara;Carretie, Luis
虽然最近的血液动力学研究表明，与情绪相关的神经活动和与反应抑制相关的神经活动构成了密切相关和相互依赖的过程，但这种关系的性质仍然不清楚。为了探讨情绪和抑制之间的相互作用的时空特征，事件相关电位（ERP）被测者（N = 30）进行了一个修改版本的Go/Nogo任务，需要在三个不同的情绪背景下抑制优势反应的中性线索：消极，中性，和积极的。采用时间和空间主成分分析以可靠的方式检测和量化与反应抑制相关的那些ERP成分（即，Nogo-N2和Nogo-P3），以及来源定位技术（sLORETA）提供了有关其神经起源的信息。行为分析表明，反应时间（RTs）在积极的情况下比在中性和消极的情况下，去线索短。ERP分析表明，抑制反应的Nogo线索在积极的背景下引起更大的额中央Nogo-P3振幅和增强前扣带皮层（ACC）激活比在消极的情况下。回归分析显示，Nogo-P3（i）与RT呈负相关，支持其与抑制优势反应相关，以及（ii）与背景效价相关（随着背景效价更加积极，振幅增加），但与背景唤醒无关。这些结果表明，在积极的效价背景下，抑制优势反应是更困难的，需要更多的抑制控制比在消极的效价背景。(C)2009 Elsevier Inc. All rights reserved.
Although recent hemodynamic studies indicate that neural activity related to emotion and that associated with response inhibition constitute closely interrelated and mutually dependent processes, the nature of this relationship is still unclear. In order to explore the temporo-spatial characteristics of the interaction between emotion and inhibition, event-related potentials (ERPs) were measured as participants (N = 30) performed a modified version of the Go/Nogo task that required the inhibition of prepotent responses to neutral cues during three different emotional contexts: negative, neutral, and positive. Temporal and spatial principal component analyses were employed to detect and quantify, in a reliable manner, those ERP components related to response inhibition (i.e., Nogo-N2 and Nogo-P3), and a source-localization technique (sLORETA) provided information on their neural origin. Behavioral analyses revealed that reaction times (RTs) to Go cues were shorter during the positive context than during neutral and negative contexts. ERP analyses showed that suppressing responses to Nogo cues within the positive context elicited larger frontocentral Nogo-P3 amplitudes and enhanced anterior cingulate cortex (ACC) activation than within the negative context. Regression analyses revealed that Nogo-P3 (i) was inversely related to RTs, supporting its association with the inhibition of a prepotent response, and (ii) was associated with contextual valence (amplitude increased as context valence was more positive), but not with contextual arousal. These results suggest that withholding a prepotent response within positively valenced contexts is more difficult and requires more inhibitory control than within negatively valenced contexts. (C) 2009 Elsevier Inc. All rights reserved.