Personal care product use among adults in NHANES: associations between urinary phthalate metabolites and phenols and use of mouthwash and sunscreen.
Personal care product use among adults in NHANES: associations between urinary phthalate metabolites and phenols and use of mouthwash and sunscreen.
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DOI：
10.1038/jes.2016.27
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发表时间：
2017-05
影响因子：
4.5
通讯作者：
Meeker JD
中科院分区：
文献类型：
--
作者：
Ferguson KK;Colacino JA;Lewis RC;Meeker JD
使用个人护理产品是显着的内分泌干扰化合物 (EDC) 的暴露途径，包括邻苯二甲酸盐、对羟基苯甲酸酯、三氯生、二苯甲酮 3 (BP3) 和双酚 A。我们利用 2009-2012 年国家健康和营养检查调查周期的问卷数据来研究具有全国代表性的美国成年人群 (n=3,529) 中防晒霜和漱口水的使用与尿液中邻苯二甲酸酯代谢物和酚类浓度之间的关联。与报告“从不”使用漱口水的人相比，报告每天使用漱口水的人尿中邻苯二甲酸单乙酯、对羟基苯甲酸甲酯和对羟基苯甲酸丙酯以及 BP3 浓度显着升高（分别高出 28%、30%、39% 和 42%）。与“从不”使用防晒霜的人相比，报告“总是”使用防晒霜的人尿中三氯生、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯和丙酯以及 BP3 浓度显着升高（分别高出 59%、92%、102%、151% 和 510%）。与男性相比，女性暴露生物标志物与防晒霜使用之间的关联更强，与女性相比，男性与漱口水使用的关联通常更强。这些结果表明防晒霜和漱口水可能是 EDC 的重要暴露源。
Personal care product use is a well-established pathway of exposure for notable endocrine disrupting compounds (EDCs), including phthalates, parabens, triclosan, benzophenone-3 (BP3), and bisphenol-A. We utilized questionnaire data from the National Health and Nutrition Examination Survey 2009–2012 cycles to examine associations between use of sunscreen and mouthwash and urinary concentrations of phthalate metabolites and phenols in a nationally representative population of US adults (n=3,529). Compared to individuals who reported “Never” using mouthwash, individuals who reported daily use had significantly elevated urinary concentrations of mono-ethyl phthalate, methyl and propyl parabens, and BP3 (28, 30, 39, and 42% higher, respectively). Individuals who reported “Always” using sunscreen had significantly higher urinary concentrations of triclosan, methyl, ethyl, and propyl parabens, and BP3 (59, 92, 102, 151, and 510% higher, respectively) compared to “Never” users of sunscreen. Associations between exposure biomarkers and sunscreen use were stronger in women compared to men, and associations with mouthwash use were generally stronger in men compared to women. These results suggest sunscreen and mouthwash may be important exposure sources for EDCs.