Long term effects of tetramine poisoning: An observational study
Long term effects of tetramine poisoning: An observational study
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DOI：
10.3109/15563650.2012.657758
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Sun, Shenggang
中科院分区：
文献类型：
--
作者：
Deng, Xuejun;Li, Gang;Sun, Shenggang
上下文毒鼠强是一种非法的鼠药，在中国已经导致了一些意外的大规模中毒事件。Objective.目的探讨毒鼠强中毒的远期疗效。材料与方法。本文对湖北省370例癫痫患者进行了调查。通过电话、信件和采访的方式，对近十年来中国毒鼠强中毒幸存者进行了调查。描述最初急性发作的数据来自医疗和公共卫生记录。结果在调查的370例患者（188例男性，182例女性，年龄范围10至71岁）中，352例在首次中毒期间发生癫痫发作。158名患者目前没有服用避孕药，平均服药时间为2.93年。其他患者有复发性癫痫，包括156例强直阵挛性发作和39例部分性发作。6名患者有其他神经问题。讨论和结论。毒鼠强是一种老鼠药，有时会被误食，它会阻断GABA受体并导致癫痫发作。这些癫痫发作可以在最初中毒后持续数年，即使最初没有癫痫发作。丙戊酸钠具有增加中枢神经系统中GABA含量的能力，是治疗毒鼠强中毒所致癫痫的合理选择。
Context. Tetramine is an illegal rat poison that has resulted in a number of accidental mass poisonings in China. Objective. To investigate the long term outcome of tetramine poisoning. Materials and methods. A survey of epileptic attacks in 370 patients in the Hubei province of P. R. China who had survived tetramine poisoning in the last decade was undertaken by means of telephone calls, letters, and interviews. Data describing the initial acute episode was gathered from medical and public health records. Results. Among the 370 patients surveyed (188 males, 182 females, age range 10 to 71 y), 352 experienced seizures during the initial poisoning. One hundred fifty-eight individuals are currently seizure-free, after an average medication period of 2.93 years. The other patients have recurrent epilepsy, including 156 with tonic-clonic seizures and 39 with partial seizures. Six patients have other neurological problems. Discussion and conclusion. Tetramine, a rat poison sometimes ingested by mistake, blocks GABA receptors and causes seizures. These seizures can persist for years after the initial poisoning, even when no seizures are present initially. Sodium valproate, which has the ability to increase the amount of GABA in the CNS, would be a reasonable choice for the treatment of epilepsy caused by tetramine poisoning.