Steroid hormone regulation of C. elegans and Drosophila aging and life history
Steroid hormone regulation of C. elegans and Drosophila aging and life history
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DOI：
10.1016/j.exger.2010.08.021
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发表时间：
2011-02-01
影响因子：
3.9
通讯作者：
Flatt, Thomas
中科院分区：
文献类型：
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作者：
Galikova, Martina;Klepsatel, Peter;Flatt, Thomas
在过去的二十年里，人们已经清楚地认识到，内分泌信号通路中的激素和基因突变对蠕虫、苍蝇、老鼠和其他生物的寿命和相关的生活史特征具有重要影响。虽然大多数研究都集中在胰岛素/胰岛素样生长因子-1信号，一种肽激素途径，但最近的研究表明，亲脂激素在调节寿命和其他生活史特征方面也起着重要作用。在这里，我们回顾了类固醇激素，一组特殊的亲脂激素，如何影响线虫（秀丽隐杆线虫）和果蝇（果蝇）的生活史特征，并特别关注寿命。有趣的是，一项比较表明，类似的内分泌原理可能在这些物种的蠕虫和苍蝇中起作用，类固醇激素与性腺相互作用，影响寿命。(C) 2010爱思唯尔公司版权所有。
In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play an important role in modulating lifespan and other life history traits. Here we review how steroid hormones, a particular group of lipophilic hormones, affect life history traits in the nematode worm (Caenorhabditis elegans) and the fruit fly (Drosophila melanogaster), with a particular focus on longevity. Interestingly, a comparison suggests that parallel endocrine principles might be at work in worms and flies in these species and that steroid hormones interact with the gonad to affect lifespan. (C) 2010 Elsevier Inc. All rights reserved.