Molecular Circuits of Resolution in Renal Disease
Molecular Circuits of Resolution in Renal Disease
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DOI：
10.1100/tsw.2010.120
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Godson, Catherine
中科院分区：
文献类型：
--
作者：
Boergeson, Emma;Godson, Catherine
炎症是肾脏病理的共同特征。脂氧素、溶血素、保护素等脂类介质通过抑制炎症部位的中性粒细胞浸润，使细胞因子环境由促炎向促炎转变，增加巨噬细胞对凋亡细胞的非炎症性吞噬作用，从而积极促进炎症的消退。在这里，我们回顾了肾脏疾病中分子回路分解的证据。
Inflammation is a common feature of renal pathology. Lipid mediators, such as lipoxins, resolvins, and protectins, can actively promote the resolution of inflammation by inhibiting polymorphonuclear cell infiltration to the site of inflammation, shifting the cytokine milieu from proinflammatory to proresolving and increasing the nonphlogistic phagocytosis of apoptotic cells by macrophages. Here we review the evidence for molecular circuits of resolution in renal disease.