Ultrasonography of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination.
Ultrasonography of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination.
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类风湿关节炎中掌pophopophanegeal和近端指间关节的超声检查：与磁共振成像，常规放射线照相和临床检查的比较。
DOI：
10.1186/ar1904
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发表时间：
2006
影响因子：
4.9
通讯作者：
Ostergaard, Mikkel
中科院分区：
文献类型：
--
作者：
Szkudlarek, Marcin;Klarlund, Mette;Narvestad, Eva;Court-Payen, Michel;Strandberg, Charlotte;Jensen, Karl E.;Thomsen, Henrik S.;Ostergaard, Mikkel
手指关节的炎症和破坏迹象是类风湿性关节炎(RA)的主要特征。很少有研究评估超声检查在检测这些体征方面的敏感性和特异性。本研究的目的是探讨超声能否提供常规放射学和临床检查所不能提供的RA手指关节炎症和破坏征象的信息，并与磁共振成像(MRI)提供的信息相媲美。对40例RA患者和20例正常对照的第2~5掌指关节和近端指间关节进行超声检查、临床检查、X线片和MRI检查。以MRI为参照物，超声诊断手指关节骨侵蚀的敏感性、特异性和准确性分别为0.59、0.98和0.96，X线检查分别为0.42、0.99和0.95。以MRI T1加权像上炎症征象为参照物，超声诊断的敏感性、特异性和准确性分别为0.70、0.78和0.76，临床检查的敏感性、特异性和准确性分别为0.40、0.85和0.72。以MRI为参照物，超声对RA指关节炎症和破坏征象的检出敏感性和准确性均高于临床和X线检查，且不丧失特异性。这项研究表明，超声检查有可能改善类风湿关节炎患者的评估。
Signs of inflammation and destruction in the finger joints are the principal features of rheumatoid arthritis (RA). There are few studies assessing the sensitivity and specificity of ultrasonography in detecting these signs. The objective of the present study was to investigate whether ultrasonography can provide information on signs of inflammation and destruction in RA finger joints that are not available with conventional radiography and clinical examination, and comparable to the information provided by magnetic resonance imaging (MRI). The second to fifth metacarpophalangeal and proximal interphalangeal joints of 40 RA patients and 20 control persons were assessed with ultrasonography, clinical examination, radiography and MRI. With MRI as the reference method, the sensitivity, specificity and accuracy of ultrasonography in detecting bone erosions in the finger joints were 0.59, 0.98 and 0.96, respectively; they were 0.42, 0.99 and 0.95 for radiography. The sensitivity, specificity and accuracy of ultrasonography, with signs of inflammation on T1-weighted MRI sequences as the reference method, were 0.70, 0.78 and 0.76, respectively; they were 0.40, 0.85 and 0.72 for the clinical examination. With MRI as the reference method, ultrasonography had higher sensitivity and accuracy in detecting signs of inflammation and destruction in RA finger joints than did clinical and radiographic examinations, without loss of specificity. This study shows that ultrasonography has the potential to improve assessment of patients with RA.
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影响因子：
27.4
作者：
Klarlund, M;Ostergaard, M;Lorenzen, I
通讯作者：
Lorenzen, I
影响因子：
27.4
作者：
McQueen, FM;Stewart, N;McLean, L
通讯作者：
McLean, L
影响因子：
--
作者：
Szkudlarek, M;Narvestad, E;Ostergaard, M
通讯作者：
Ostergaard, M
影响因子：
--
作者：
Ejbjerg, B;Narvestad, E;Ostergaard, M
通讯作者：
Ostergaard, M
影响因子：
--
作者：
Terslev, L;Torp-Pedersen, S;Bliddal, H
通讯作者：
Bliddal, H