Infrastructure for the life sciences: design and implementation of the UniProt website.
Infrastructure for the life sciences: design and implementation of the UniProt website.
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DOI：
10.1186/1471-2105-10-136
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发表时间：
2009-05-08
影响因子：
3
通讯作者：
Gasteiger E
中科院分区：
文献类型：
--
作者：
Jain E;Bairoch A;Duvaud S;Phan I;Redaschi N;Suzek BE;Martin MJ;McGarvey P;Gasteiger E
该联盟由瑞士生物信息学研究所（SIB），欧洲生物信息学研究所（EBI）和乔治敦大学的蛋白质信息资源（PIR）组成，于2002年成立，不久之后，该网站是作为中央入境而设置的。指向Uniprot资源。该地址的请求将其重定向到三个组织的网站之一。尽管这些站点与有关Uniprot的一般信息共享了一组静态页面，但它们的搜索和查看数据页面却不同。为了为用户提供一致的视图并削减维护三个单独的站点的成本，该财团决定开发一个通用的Uniprot网站。在经过数年的激烈发展和一年的公共测试测试之后，该领域被切换到2008年7月本文中描述的新开发的网站。
Uniprot联盟是许多生命科学社区的蛋白质序列和注释数据的主要提供商。该网站是此数据的主要访问点，以及数据的文档和基本工具。这些工具包括全文和基于字段的文本搜索，相似性搜索，多个序列对齐，批次检索和数据库标识符映射。本文讨论了2008年7月发布的新网站的设计和实施，并显示了它如何改善具有不同经验级别的用户以及用于程序化访问的机器的数据访问。
为学术和商业用途开放。该网站是使用开源工具和库构建的。反馈非常欢迎，应发送到help@uniprot.org。
新的Uniprot网站使访问和理解Uniprot比以往任何时候都更加容易。汲取的两个主要课程是，获得此类数据提供商网站的基础知识具有巨大的好处，但并不容易低估，并且在整个开发过程中都无法使用经验数据来决定什么是什么和什么对您的用户不起作用。
The UniProt consortium was formed in 2002 by groups from the Swiss Institute of Bioinformatics (SIB), the European Bioinformatics Institute (EBI) and the Protein Information Resource (PIR) at Georgetown University, and soon afterwards the website was set up as a central entry point to UniProt resources. Requests to this address were redirected to one of the three organisations' websites. While these sites shared a set of static pages with general information about UniProt, their pages for searching and viewing data were different. To provide users with a consistent view and to cut the cost of maintaining three separate sites, the consortium decided to develop a common website for UniProt. Following several years of intense development and a year of public beta testing, the domain was switched to the newly developed site described in this paper in July 2008. The UniProt consortium is the main provider of protein sequence and annotation data for much of the life sciences community. The website is the primary access point to this data and to documentation and basic tools for the data. These tools include full text and field-based text search, similarity search, multiple sequence alignment, batch retrieval and database identifier mapping. This paper discusses the design and implementation of the new website, which was released in July 2008, and shows how it improves data access for users with different levels of experience, as well as to machines for programmatic access. is open for both academic and commercial use. The site was built with open source tools and libraries. Feedback is very welcome and should be sent to help@uniprot.org. The new UniProt website makes accessing and understanding UniProt easier than ever. The two main lessons learned are that getting the basics right for such a data provider website has huge benefits, but is not trivial and easy to underestimate, and that there is no substitute for using empirical data throughout the development process to decide on what is and what is not working for your users.
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影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
5.8
作者：
Leinonen, R;Nardone, F;Apweiler, R
通讯作者：
Apweiler, R
影响因子：
9.5
作者：
Bairoch, A;Boeckmann, B;Gasteiger, E
通讯作者：
Gasteiger, E
影响因子：
12.3
作者：
Mons B;Ashburner M;Chichester C;van Mulligen E;Weeber M;den Dunnen J;van Ommen GJ;Musen M;Cockerill M;Hermjakob H;Mons A;Packer A;Pacheco R;Lewis S;Berkeley A;Melton W;Barris N;Wales J;Meijssen G;Moeller E;Roes PJ;Borner K;Bairoch A
通讯作者：
Bairoch A