SECONDARY MALIGNANT GIANT-CELL TUMOR OF BONE - CLINICOPATHOLOGICAL ASSESSMENT OF 19 PATIENTS
SECONDARY MALIGNANT GIANT-CELL TUMOR OF BONE - CLINICOPATHOLOGICAL ASSESSMENT OF 19 PATIENTS
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DOI：
10.2106/00004623-198668070-00016
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发表时间：
1986-09-01
影响因子：
5.3
通讯作者：
DAHLIN, DC
中科院分区：
文献类型：
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作者：
ROCK, MG;SIM, FH;DAHLIN, DC
梅奥诊所已经发现了26例患有骨恶性巨细胞瘤的患者，这种肉瘤要么与典型的良性巨细胞瘤并列，要么发生在先前记录的良性巨细胞瘤的部位。在26例肿瘤中，19例是继发于先前对良性巨细胞肿瘤进行局部控制的尝试。这19例继发性肿瘤患者中除1例外均在4至39年前接受过治疗性放疗。恶性巨细胞瘤的症状性质、持续时间及好发部位与良性巨细胞瘤相同。纤维肉瘤的发生率是骨肉瘤的三倍。早期消融治疗继发性肉瘤的效果最好。
Twenty-six patients who had a malignant giant-cell tumor of bone-a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor-have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt to local control of benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treamtent of the secondary sarcoma were obtained with early ablation.