Giant Suppression of Photobleaching for Single Molecule Detection via the Purcell Effect
Giant Suppression of Photobleaching for Single Molecule Detection via the Purcell Effect
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DOI：
10.1021/nl403047m
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发表时间：
2013-12-01
期刊：
影响因子：
10.8
通讯作者：
Zhang, Xiang
中科院分区：
文献类型：
--
作者：
Cang, Hu;Liu, Yongmin;Zhang, Xiang
我们报告了通过等离子体纳米结构中的Purcell效应对光漂白的巨大抑制和单荧光分子寿命的延长。等离子体结构增强了受激荧光分子的自发发射，减少了激活破坏分子的光化学反应的可能性，从而抑制了漂白。在实验中，我们观察到，在单个荧光分子漂白之前，我们可以从单个荧光分子中收获的光子总数增加了1000倍。这种方法证明了利用珀塞尔效应在亚波长尺度上操纵光化学反应的潜力。
We report giant suppression of photobleaching and a prolonged lifespan of single fluorescent molecules via the Purcell effect in plasmonic nanostructures. The plasmonic structures enhance the spontaneous emission of excited fluorescent molecules, reduce the probability of activating photochemical reactions that destroy the molecules, and hence suppress the bleaching. Experimentally, we observe up to a 1000-fold increase in the total number of photons that we can harvest from a single fluorescent molecule before it bleaches. This approach demonstrates the potential of using the Purcell effect to manipulate photochemical reactions at the subwavelength scale.