Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation
Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation
复制标题
DOI：
10.1016/s0306-4530(02)00005-7
复制
发表时间：
2003-01-01
影响因子：
3.7
通讯作者：
Dantzer, R
中科院分区：
文献类型：
--
作者：
Castanon, N;Konsman, JP;Dantzer, R
抗抑郁药天奈汀已被证明可以降低下丘脑-垂体-肾上腺（HPA）轴对应激的反应，并减弱细胞因子诱导剂脂多糖（LPS）的行为效应。由于LPS也激活HPA轴，本研究的目的是评估天奈汀对腹腔注射LPS（分别为30和250马克杯/千克）诱导的HPA轴激活和Fos表达的影响。慢性而非急性天奈汀治疗（10 mg/kg，每天2次，连用15天，ip）可减弱lps诱导的颈静脉留置导管大鼠血浆ACTH和皮质酮的升高以及室旁核（PVN） Fos的免疫反应性。这些结果为天奈肽的药理活性开辟了新的前景，并为临床抗抑郁药物的作用机制提供了进一步的见解。(C) 2002 Elsevier Science Ltd.版权所有。
The antidepressant tianeptine has been shown to decrease the response of the hypothalamic-pituitary-adrenal (HPA) axis to stress and to attenuate the behavioral effects of the cytokine inducer, lipopolysaccharide (LPS). Since LPS also activates the HPA axis, the objective of this study was to assess the effects of tianeptine on the HPA axis activation and Fos expression induced by intraperitoneal (ip) administration of LPS (30 and 250 mug/kg respectively). Chronic, but not acute, tianeptine treatment (10 mg/kg twice a day for 15 days, ip) attenuated LPS-induced increase of plasma ACTH and corticosterone in rats bearing an indwelling catheter in the jugular vein and Fos immunoreactivity in the paraventricular nucleus (PVN). These results open new vistas on the pharmacological activity of tianeptine and provide further insights on the action mechanisms of antidepressants in clinics. (C) 2002 Elsevier Science Ltd. All rights reserved.