Trials which randomize practices I: how should they be analysed?
Trials which randomize practices I: how should they be analysed?
复制标题
随机化实践的试验 I：应该如何分析它们？
作者：
S. Kerry;J. Bland
背景
在一些全科医学干预试验中，患者必须在实践中随机分配，而不是单独分配，并且在分析中必须考虑到这一点。
目标
在这篇文章中，我们的目的是显示如何不这样做可能会导致虚假的统计学意义和CI比他们应该是窄，并描述使用汇总措施，为每一个实践作为一个简单的分析方法。
方法
通过一个在一般实践中的试验的例子证明了统计问题。
讨论
如果每个诊所招募了大量患者或诊所之间存在高度差异，则分析单位的选择将是最重要的。
BACKGROUND
In some general practice intervention trials, patients must be randomized in practices rather than individually, and this must be taken into account in the analysis.
OBJECTIVES
In this article we aim to show how failure to do this may lead to spurious statistical significance and CIs which are narrower than they should be, and to describe the use of summary measures for each practice as a simple method of analysis.
METHOD
The statistical issues are demonstrated by an example of a trial in general practice.
DISCUSSION
The choice of unit of analysis will be most important where there are large numbers of patients recruited from each practice or a high degree of variability between practices.