Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
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DOI：
10.1016/j.eplepsyres.2008.03.011
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发表时间：
2008-07-01
影响因子：
2.2
通讯作者：
Chugani, Harry T.
中科院分区：
文献类型：
--
作者：
Govindan, Rajkumar Munian;Makki, Malek I.;Chugani, Harry T.
目的：探讨颞叶癫痫患者颞叶白质束是否表现出异常的水扩散特性。方法：对13例左颞叶癫痫患儿和正常常规MRI进行钩侧、弓形、下纵束和皮质脊髓束的磁共振弥散张量成像，并与12例年龄匹配的正常志愿者进行比较。测定张量参数与癫痫持续时间的关系。结果：与对照组相比，受影响的左半球所有四个束的平均各向异性、平面和线性指数均较低，但球形指数较高。左钩状束和弓状束弥散变化与癫痫持续时间显著相关。弓形束显示正常左右不对称的逆转。在右半球的四个束中也可见各种扩散异常。结论：我们的研究结果表明，颞叶和颞叶外束的水扩散异常，在垂直于轴突的方向上有明显的变化。与癫痫持续时间相关的弥散异常提示同侧钩状束和弓形束由于慢性发作活动而发生进行性改变。最后，弓形神经束的结果与对侧右半球的语言重组一致。(C) 2008 Elsevier B.V.版权所有
Objective: To determine whether the major temporal lobe white matter tracts in patients with temporal lobe epilepsy manifest abnormal water diffusion properties.Methods: Diffusion tensor MRI measurements were obtained from tractography for uncinate, arcuate, inferior longitudinal fasciculi and corticospinal tract in 13 children with left temporal lobe epilepsy and normal conventional MRI, and the data were compared to measurements in 12 age-matched normal volunteers. The relationship between tensor parameters and duration of epilepsy was also determined.Results: All four tracts in the affected left hemisphere showed lower mean anisotropy, planar and linear indices, but higher spherical index in patients versus controls. Diffusion changes in the left uncinate and arcuate fasciculus correlated significantly with duration of epilepsy. Arcuate fasciculus showed a reversal of the normal left-right asymmetry. Various diffusion abnormalities were also seen in the four tracts studied in the right hemisphere.Conclusion: Our findings indicate abnormal water diffusion in temporal lobe and extra-temporal lobe tracts with robust changes in the direction perpendicular to the axons. Diffusion abnormalities associated with duration of epilepsy suggest progressive changes in ipsilateral uncinate and arcuate fasciculus due to chronic seizure activity. Finally, our results in arcuate fasciculus are consistent with language reorganization to the contralateral right hemisphere. (C) 2008 Elsevier B.V. All rights reserved.