Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation.
Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation.
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氧化脂质和脂蛋白在炎症中的上下文依赖性作用。
DOI：
10.1016/j.tem.2016.11.002
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Shyy JY
中科院分区：
文献类型：
--
作者：
Miller YI;Shyy JY
氧化型低密度脂蛋白（OxLDL）含有数百种不同的氧化脂质分子，是高脂血症和动脉粥样硬化的标志。在OxLDL中发现的相同氧化脂质也在凋亡细胞中形成，并且在病理条件下存在于组织和循环中。在许多疾病背景下，氧化脂质构成损伤信号或模式，激活模式识别受体并显著促进炎症。本文综述了氧化脂质和炎症调节领域的最新发现和新趋势，重点是酯化成胆固醇酯和磷脂的多不饱和脂肪酸的氧化产物。该论文强调了TLR4和NLRP3炎性体的上下文依赖性激活和偏向性激动，以及氧化脂质激活的其他信号通路。
Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids found in OxLDL are also formed in apoptotic cells, and are present in tissues as well as in the circulation under pathological conditions. In many disease contexts, oxidized lipids constitute damage signals, or patterns, that activate pattern-recognition receptors and significantly contribute to inflammation. This article reviews recent discoveries and emerging trends in the field of oxidized lipids and regulation of inflammation, focusing on oxidation products of polyunsaturated fatty acids esterified into cholesteryl esters and phospholipids. The paper highlights context-dependent activation and biased agonism of TLR4 and the NLRP3 inflammasome, among other signaling pathways activated by oxidized lipids.