Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us.
Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us.
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DOI：
10.1016/j.jacc.2015.08.025
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发表时间：
2015-10-06
影响因子：
24
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Malik VS;Hu FB
最近的注意力集中在果糖在心脏代谢疾病的发病机制中具有独特的作用。然而，由于我们很少单独食用果糖，饮食中果糖的主要来源来自含果糖的糖，蔗糖和高果糖玉米糖浆，含糖饮料。在不同人群中，这些饮料的摄入量一直与肥胖、2型糖尿病和心血管疾病的风险增加有关。推测的潜在机制包括液体热量的不完全补偿、不良血糖效应和果糖的肝脏代谢增加，导致从头脂肪生成、尿酸产生以及内脏和异位脂肪积累。在这篇综述中，我们总结了流行病学和临床试验的证据，评估添加糖，特别是含糖饮料，肥胖，糖尿病和心血管疾病的风险，解决潜在的生物学机制，重点是果糖生理学。我们还讨论了减少含果糖饮料摄入量的策略。
Recent attention has focused on fructose as having a unique role in the pathogenesis cardiometabolic diseases. However since we rarely consume fructose in isolation, the major source of fructose in the diet comes from fructose-containing sugars, sucrose and high fructose corn syrup, in sugar sweetened beverages. Intake of these beverages has been consistently linked to increased risk of obesity, type 2 diabetes and cardiovascular disease in various populations. Putative underlying mechanisms include incomplete compensation for liquid calories, adverse glycemic effects and increased hepatic metabolism of fructose leading to de novo lipogenesis, production of uric acid and accumulation of visceral and ectopic fat. In this review we summarize the epidemiological and clinical trial evidence evaluating added sugars especially sugar-sweetened beverages, and risk of obesity, diabetes and cardiovascular disease addressing potential biological mechanisms with an emphasis on fructose physiology. We also discuss strategies to reduce intake of fructose-containing beverages.