HUMAN SINUS ARRHYTHMIA AS AN INDEX OF VAGAL CARDIAC OUTFLOW
HUMAN SINUS ARRHYTHMIA AS AN INDEX OF VAGAL CARDIAC OUTFLOW
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DOI：
10.1152/jappl.1983.54.4.961
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
ECKBERG, DL
中科院分区：
文献类型：
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作者：
ECKBERG, DL
由于心动周期的变化与心脏迷走神经传出活动的变化密切相关，且波幅几乎固定，因此，呼吸性窦性心律失常的测量可能有助于了解人类中枢迷走神经机制。测量了6名健康青年男女在控制呼吸期间（呼吸间隔为2.5-10 s，标称潮气量为1000和1500 ml）心跳之间的间隔。随着呼吸间隔的增加，最长心动周期逐渐变长，最短心动周期逐渐变短，峰谷P-P间期逐渐增加。峰谷P-P间期也随潮气量增加而增加。这种影响很小：潮气量增加50%，平均峰-谷P-P间隔仅增加约百分之十五心动周期变化与呼吸之间的相位角随呼吸间隔的线性变化而变化。心脏周期缩短（心脏加速）开始于短呼吸间隔的吸气和长呼吸间隔的呼气。然而，在所有研究的呼吸间隔中，心率延长都始于呼气早期。这些结果表明，在清醒的人中，呼吸深度和呼吸间隔的变化与迷走神经心脏流出的数量、周期和时间之间存在密切关系。在正常的呼吸频率下，迷走神经运动神经元活动的阶段性呼吸相关变化开始于呼气，进展缓慢，并且在快呼吸频率下不完全表达。
Since changes of heart period follow changes of cardiac vagal efferent activity quantitatively with nearly fixed latencies, measurments of respiratory sinus arrhythmia may provide insights into human central vagal mechanisms. Intervals were measured between heart-beats during controlled breathing (at breathing intervals of 2.5-10 s and nominal tidal volumes of 1000 and 1500 ml) in 6 healthy young men and women. As the breathing interval increased, the longest heart periods became longer, the shortest heart periods became shorter and the peak-valley P-P intervals increased asymptotically. Peak-valley P-P intervals also increased in proportion to tidal volume. This influence was small: a 50% increase of tidal volume increased the average peak-valley P-P interval by only .apprx. 15%. The phase angles between heart period changes and respiration varied as linear functions of breathing interval. Heart period shortening (cardioacceleration) began in inspiration at short breathing intervals and in expiration at long breathing intervals. Heart period lengthening, however, began in early expiration at all breathing intervals studied. These results point toward a close relationship between variations of respiratory depth and interval and the quantity, periodicity and timing of vagal cardiac outflow in conscious humans. At usual breathing rates, phasic respiration-related changes of vagal motoneuron activity begin in expiration, progress slowly and are incompletely expressed at fast breathing rates.