URSODEOXYCHOLIC ACID - A SAFE AND EFFECTIVE AGENT FOR DISSOLVING CHOLESTEROL GALLSTONES
URSODEOXYCHOLIC ACID - A SAFE AND EFFECTIVE AGENT FOR DISSOLVING CHOLESTEROL GALLSTONES
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DOI：
10.7326/0003-4819-97-3-351
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发表时间：
1982-01-01
影响因子：
39.2
通讯作者：
SHEFER, S
中科院分区：
文献类型：
--
作者：
TINT, GS;SALEN, G;SHEFER, S
熊去氧胆酸250~300 mg/d，500~600 mg/d，900~1000 mg/d，连服6~38mo。对53例胆固醇结石和正常胆囊者，42例结石体积和/或数量减少了50%，没有明显的剂量依赖关系，其中27例结石完全溶解。包括肝功能测试在内的实验室研究结果在治疗期间没有受到不利影响，胆汁中胆石胆酸浓度也没有增加。大部分胆道症状似乎在3个月内消失。无一例患者出现腹泻。大直径和数量增加的胆结石被发现阻碍了溶解。胆汁熊去氧胆酸的百分比随剂量的增加而增加，在.apprx剂量时，胆汁中熊去氧胆酸占总胆汁酸的百分比达到最大值50-60%。每天10-12毫克/公斤体重。熊去氧胆酸500-600 mg/d和900-1000 mg/d治疗后胆汁成石指数明显降低。熊去氧胆酸似乎是一种安全有效的手术替代方案，适用于部分胆结石患者。
Ursodeoxycholic acid, 250-300, 500-600 or 900-1000 mg/day, was given orally for 6-38 mo. to 53 patients with cholesterol gallstones and functioning gallbladders; 42 patients had > 50% reduction in gallstone volume and/or number without apparent dose dependence and 27 of these patients had complete gallstone dissolution. Results of laboratory studies including liver function tests were not affected adversely and biliary lithocholic acid concentration did not increase during therapy. Most biliary symptoms seemed to disappear within 3 mo. and no patient developed diarrhea. Large diameter and increased number of gallstones were found to hinder dissolution. The percentage of biliary ursodeoxycholic acid increased with increasing dose and reached a maximum of 50-60% of total bile acids at a dose of .apprx. 10-12 mg/kg body wt per day. Biliary lithogenic index was reduced significantly during treatment with ursodeoxycholic acid 500-600 and 900-1000 mg/day. Ursodeoxycholic acid appears to be a safe and effective alternative to surgery in selected patients with gallstones.