OPINION Myelination and the trophic support of long axonss
OPINION Myelination and the trophic support of long axonss
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DOI：
10.1038/nrn2797
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发表时间：
2010-04-01
影响因子：
34.7
通讯作者：
Nave, Klaus-Armin
中科院分区：
文献类型：
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作者：
Nave, Klaus-Armin
除了在为快速冲动传导提供髓鞘方面的作用外，包裹长轴突的神经胶质细胞对于维持正常的轴突运输和长期存活也是必需的。这种可能是原始的功能似乎与髓鞘膜的包裹无关。在此，我提出包裹神经胶质细胞为代谢孤立的轴突提供营养支持，而髓鞘本身可能导致这种孤立。这种神经胶质对轴突完整性的支持可能与许多神经和精神疾病相关。
In addition to their role in providing myelin for rapid impulse propagation, the glia that ensheath long axons are required for the maintenance of normal axon transport and long-term survival. This presumably ancestral function seems to be independent of myelin membrane wrapping. Here, I propose that ensheathing glia provide trophic support to axons that are metabolically isolated, and that myelin itself might cause such isolation. This glial support of axonal integrity may be relevant for a number of neurological and psychiatric diseases.