Influence of Lactobacillus crispatus, Lactobacillus iners and Gardnerella vaginalis on bacterial vaginal composition in pregnant women.
Influence of Lactobacillus crispatus, Lactobacillus iners and Gardnerella vaginalis on bacterial vaginal composition in pregnant women.
复制标题
卷曲乳杆菌、惰性乳杆菌和阴道加德纳菌对孕妇阴道细菌组成的影响。
DOI：
10.1007/s00404-021-05978-z
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发表时间：
2021
影响因子：
2.6
通讯作者：
Forney,LarryJ
中科院分区：
文献类型：
--
作者：
Witkin,StevenS;Moron,AntonioF;Linhares,IaraM;Forney,LarryJ
PurposeTo investigate associations between bacteria species in the vagina in mid-trimester pregnant women from Brazil.MethodsThe vaginal microbiome in 613 subjects was identified by analysis of V1-V3 region of bacterial 16S ribosomal RNA and relative prevalence of individual bacterial were determined.ResultsThe bacteria species present in the most number of women were Lactobacillus crispatus（306 women），L.阴道加德纳菌（179例）。当存在于阴道中时，L.在85%以上的时间里，crispatus是最丰富的细菌。与此相反，L.内桑德湾阴道炎在这些微生物阳性的妇女中分别占63%和41%（p< 0.0001 vs.L. crispatus）。卷曲乳杆菌的比例与乳杆菌的比例呈负相关。伊内斯湖詹氏湖gasseri，G. vagoniae、Megasphaera、Atopobium vaginae和Prevotella的比例差异显著（p < 0.0001）。阴道炎与巨球菌、A. vaginae和Prevotella（p< 0.0001），L. iners的比例与L的比例无关。jensenii，黑腹隐翅虫G. vagulina，Megaspaera，A.结论妊娠中期妇女阴道菌群的组成受L. crispatus，L.内桑德湾流浪汉
PurposeTo investigate associations between bacterial species in the vagina in mid-trimester pregnant women from Brazil.MethodsThe vaginal microbiome in 613 subjects was identified by analysis of the V1–V3 region of bacterial 16S ribosomal RNA and the relative prevalence of individual bacteria were determined.ResultsThe bacterial species present in the greatest number of women wereLactobacillus crispatus(306 women), L. iners(298 women) andGardnerella vaginalis(179 women). When present in the vagina,L. crispatuswas the most abundant bacterium more than 85% of the time. In contrast,L. inersandG. vaginaliswere most abundant in 63% and 41% of women who were positive for these microorganisms, respectively (p< 0.0001 vs.L. crispatus). The proportion ofL.crispatus was negatively associated with the proportions ofL. iners, L. jensenii, L. gasseri, G. vaginalis, Megasphaera, Atopobium vaginaeandPrevotella(p < 0.0001).In contrast, the proportion ofG. vaginaliswas positively associated with levels ofMegasphaera, A. vaginaeandPrevotella(p< 0.0001) whileL. inersproportion was unrelated to the proportion ofL. jensenii, G. vaginalis, Megasphaera, A. vaginaeorPrevotella.ConclusionThe composition of the vaginal microbiota in mid-trimester pregnant women is influenced by the relative concentrations ofL. crispatus, L. inersandG. vaginalis.