Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans.
Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans.
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DOI：
10.14814/phy2.12262
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Muzik O
中科院分区：
文献类型：
--
作者：
Hew-Butler T;Landis-Piwowar K;Byrd G;Seimer M;Seigneurie N;Byrd B;Muzik O
鸢尾素是一种激素，通过将啮齿类动物的皮下白色脂肪转化为棕色脂肪，模仿与定期运动相关的有利代谢效应。对 33 名受试者（16 名跑步者，17 名非跑步者）进行了测量：静息能量消耗 (REE)、身体成分、VO2 峰值测试、[irisin]p 和血浆代谢概况。随后，9 名女性非跑步者参加了为期 10 周的 5 公里监督训练计划，并在赛后进行了测试。两名跑步者接受了 18F-FDG-PET 扫描以量化棕色脂肪。匹配队列之间没有发现性别或年龄（28 ± 10 岁）差异。跑步者在 13 ± 6 年内平均每周跑步 58 ± 26 英里，体重较低（63 vs. 88 kg；P < 0.001）、BMI（21 vs. 30 kg/m2；P < 0.0001）、甘油三酯（58 vs. 123 mg/dL；P < 0.01）、总（白色）脂肪（14% vs. 32%；P < 0.01）。与非跑步者相比，他们的摄氧量峰值（63 vs. 34 mL/kg-min；P < 0.0001）和 HDL（65 vs. 48 mg/dL；P < 0.01）更高。在 VO2 峰值测试之前（179 与 197 ng/mL；NS）和之后（207 与 226 ng/mL；NS），跑步者的 [Irisin]p 低于非跑步者。 [irisin]p 与 BMI (r2 = 0.15)、甘油三酯 (r2 = 0.40) 和全身脂肪 (g) (r2 = 0.24) 之间存在显着正相关 (P < 0.05)，而 [irisin]p 与呼吸商之间存在显着负相关 (r2 = 0.33)。总瘦体重与 REE 显着相关 (r2 = 0.58)，而总脂肪质量与 VO2 峰值呈负相关 (r2 = 0.64)。完成训练计划后，非跑步者的 [irisin]p 较低（194 vs.181 ng/mL；训练前后；P > 0.05）。被选进行 18F-FDG-PET 扫描的跑步者都没有棕色脂肪。与非跑步者相比，跑步者表现出明显更健康的代谢和身体成分。这些有利的运动效果均与[鸢尾素]p呈正相关。与健康、久坐、年龄和性别匹配的超重个体相比，训练有素的精英跑步者没有可检测到的棕色脂肪，且血浆鸢尾素水平较低。定期跑步对代谢健康的益处也与血浆鸢尾素水平升高无关。超重久坐女性进行 10 周 5 公里跑步计划后，血浆鸢尾素水平下降。
Irisin is a hormone which mimics the favorable metabolic effects associated with regular exercise, by converting subcutaneous white fat into brownish fat, in rodents. Thirty‐three human subjects (16 runners, 17 nonrunners) were measured for: resting energy expenditure (REE), body composition, VO2 Peak test, [irisin]p, and plasma metabolic profile. Nine female nonrunners then participated in a 10‐week supervised 5 km training program and tested after the race. Two runners underwent 18F‐FDG‐PET scans to quantify brown fat. No gender or age (28 ± 10 years) differences noted between matched cohorts. Runners averaged 58 ± 26 miles/week for 13 ± 6 years and had lower bodyweight (63 vs. 88 kg; P < 0.001), BMI (21 vs. 30 kg/m2; P < 0.0001), triglycerides (58 vs. 123 mg/dL; P < 0.01), total (white) fat (14 vs. 32%; P < 0.0001), and had higher VO2 Peak (63 vs. 34 mL/kg‐min; P < 0.0001) and HDL (65 vs. 48 mg/dL; P < 0.01) compared with nonrunners. [Irisin]p was lower in runners versus nonrunners both before (179 vs. 197 ng/mL; NS) and after (207 vs. 226 ng/mL; NS) the VO2 Peak test. Significant (P < 0.05) positive correlations were noted between [irisin]p versus BMI (r2 = 0.15), triglycerides (r2 = 0.40), and total body fat(g) (r2 = 0.24) with a significant negative correlation between [irisin]p versus respiratory quotient (r2 = 0.33). Total lean mass significantly correlated with REE (r2 = 0.58) while total fat mass inversely correlated with VO2 Peak (r2 = 0.64). Nonrunners had lower [irisin]p after completion of the training program (194 vs.181 ng/mL; pre‐ to post‐training; P > 0.05). Neither runner selected for 18F‐FDG‐PET scans had brown fat. Runners demonstrated significantly healthier metabolic and body composition profiles compared with nonrunners. None of these favorable exercise effects were positively associated with [irisin]p.. Well‐trained and elite runners had no detectable brown fat and lower plasma irisin levels compared to healthy, sedentary, age and gender‐matched overweight individuals. The metabolic health benefits of regular running were also not associated with elevated plasma irisin levels. Plasma irisin levels decreased after a 10‐week 5 km running program in overweight sedentary females.