Effects of extinction context and retrieval cues on renewal of alcohol-cue reactivity among alcohol-dependent outpatients.
Effects of extinction context and retrieval cues on renewal of alcohol-cue reactivity among alcohol-dependent outpatients.
复制标题
消退背景和检索线索对酒精依赖门诊患者酒精线索反应更新的影响。
DOI：
10.1037/0893-164x.21.2.244
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Bradizza,ClaraM
中科院分区：
文献类型：
--
作者：
Stasiewicz,PaulR;Brandon,ThomasH;Bradizza,ClaraM
Pavlovian conditioning models have led to cue-exposure treatments for drug abuse. However, conditioned responding to drug stimuli can return (be renewed) following treatment. Animal research and a previous study of social drinkers indicated that extinction is highly context dependent but that renewal could be reduced by the inclusion of a cue from the extinction context. This study extends this research to a clinical sample. Alcohol-dependent outpatients (N= 143) completed an extinction trial to reduce craving and salivation responses to alcohol cues. They were then randomized to renewal tests in either the same context as extinction, a different context, the different context containing an extinction cue, or the different context with cue plus a manipulation to increase the salience of the cue. Contrary to predictions, the different context did not produce the expected renewal effect. Although the generalization of extinction effects beyond the cue-exposure context is a positive clinical finding, it is inconsistent with basic research findings on the context dependence of extinction. Possible explanations for this inconsistency are discussed.(PsycINFO Database Record (c) 2019 APA, all rights reserved)
