Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital.
Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital.
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DOI：
10.2147/rmhp.s277963
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发表时间：
2020
影响因子：
3.5
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Cheng K;He M;Shu Q;Wu M;Chen C;Xue Y
感染监测和危险因素分析是预防和治疗医院细菌感染的重要前提之一，这是感染和非感染患者的需求。探讨COVID-19患者医院细菌感染的危险因素，为科学预防和控制医院细菌感染提供理论依据。于2020年1月10日至2020年3月9日期间，我们收集了212名COVID-19患者的数据，然后通过回顾性研究探讨了年龄、性别、住院时间、呼吸机使用、导尿、中心静脉置管、白色血细胞（WBC）计数和降钙素原对COVID-19患者医院细菌感染的影响。新冠肺炎确诊病例212例，其中院内细菌感染31例，发生率14. 62%。医院感染细菌种类以下呼吸道感染最多（12例，38.71%），其次为泌尿道感染（10例，32.26%）、血流感染（7例，22.58%）、上呼吸道感染（1例，3.23%）和胃肠道感染（1例，3.23%）。院内细菌感染发生率与年龄、动静脉置管、导尿、白细胞计数、降钙素原等因素显著相关。此外，多变量分析证实WBC（OR 8.38，95%CI 1.07 ~ 65.55）、降钙素原（OR 4.92，95%CI 1.39 ~ 17.33）和导尿（OR 25.38，95%CI 5.09 ~ 126.53）是COVID-19患者医院细菌感染的独立危险因素。了解COVID-19患者医院细菌感染的危险因素，加强对各种易感因素的监测，有助于控制COVID-19隔离病房医院细菌感染的发生。
Infection surveillance and risk factor analysis are among the most important prerequisites for the prevention and treatment of nosocomial bacteria infections, which are the demands for both infected and non-infected patients. To explore the risk factors for nosocomial bacterial infection of patients with COVID-19, and further to provide a theoretical basis for scientific prevention and control of nosocomial bacterial infection. Between 10 January 2020 and 9 March 2020, we collected data of 212 patients with COVID-19 and then explored the influence of age, gender, length of stay, use of ventilator, urinary catheterization, central venous catheterization, white blood cell (WBC) count and procalcitonin on the nosocomial bacterial infection of patients with COVID-19 by a retrospective study. There were 212 confirmed cases of COVID-19, of which 31 cases had nosocomial bacterial infections, with an incidence of 14.62%. The most common types of nosocomial bacterial infections were lower respiratory tract (12 cases, 38.71%), which was the most frequent site, followed by urinary tract (10 cases, 32.26%), blood stream (7 cases, 22.58%), upper respiratory tract (1 case, 3.23%) and gastrointestinal tract infection (1 case, 3.23%). The incidence of nosocomial bacterial infection was significantly correlated with age, arteriovenous catheterization, urinary catheterization, WBC count and procalcitonin. Moreover, multivariate analysis confirmed that WBC (OR 8.38, 95% CI 1.07 to 65.55), procalcitonin (OR 4.92, 95% CI 1.39 to 17.33) and urinary catheterization (OR 25.38, 95% CI 5.09 to 126.53) were independent risk factors for the nosocomial bacterial infection of patients with COVID-19. Understanding the risk factors for nosocomial bacterial infection of patients with COVID-19 and strengthening the monitoring of various susceptible factors are helpful to control the occurrence of nosocomial bacterial infection in the COVID-19 isolation wards.