Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion.
Activation of GABA B receptors in the anterior pituitary inhibits prolactin and luteinizing hormone secretion.
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垂体前叶 GABA B 受体的激活会抑制催乳素和黄体生成素的分泌。
DOI：
10.1159/000126294
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发表时间：
1992
影响因子：
4.1
通讯作者：
Carlos Libertun
中科院分区：
文献类型：
--
作者：
V. Lux;E. Rey;Carlos Libertun
我们实验室的先前工作表明，巴氯芬可以降低作用于中枢神经系统的血清催乳素（PRL）水平。本实验旨在评价γ-氨基丁酸B激动剂是否也有效抑制垂体水平的激素释放。在单层培养的腺垂体分散细胞，巴氯芬抑制基础PRL分泌后1或2小时的孵育。三种拮抗剂：法氯芬，3-氨基丙基膦酸和4-氨基丁基膦酸，这种抑制作用显着取消。此外，巴氯芬浓度依赖性地抑制促甲状腺素释放酶诱导的PRL释放。在促性腺激素分泌方面，巴氯芬不能改变基础促黄体生成素（LH）的分泌，但显著抑制LH释放酶诱导的LH释放。这些结果表明，巴氯芬，除了其中枢神经内分泌作用，抑制垂体激素分泌，在基础和/或刺激条件下，通过直接作用于垂体水平。
Previous work from our laboratory showed that baclofen could lower serum prolactin (PRL) levels acting at the central nervous system. The present experiments were designed to evaluate whether the gamma-aminobutyric acid B agonist was also effective in inhibiting hormone release at the pituitary level. In monolayer cultures of adenohypophyseal dispersed cells, baclofen inhibited basal PRL secretion after 1 or 2 h of incubation. This inhibition was significantly abolished by three antagonists: phaclofen, 3-aminopropyl-phosphonic acid and 4-aminobutylphosphonic acid. Furthermore, baclofen inhibited the thyrotropin-releasing hormone-induced PRL release in a concentration-dependent manner. With regard to gonadotropin secretion, baclofen was unable to modify basal luteinizing hormone (LH) secretion, but significantly inhibited the LH-releasing hormone-induced LH release. These results show that baclofen, in addition to its central neuroendocrine effects, inhibits pituitary hormone secretion, under basal and/or stimulated conditions, by direct action at the pituitary level.