Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning.
Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning.
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DOI：
10.1101/lm.1912510
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发表时间：
2010-10-01
期刊：
影响因子：
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通讯作者：
McNally, Gavan P
中科院分区：
文献类型：
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作者：
Chan, Wan Yee Macy;Leung, Hiu T;McNally, Gavan P
在六个实验中，我们研究了在消退训练（消退-再巩固边界）之前，单次重新暴露于条件刺激（CS；“检索试验”）对恐惧消退发展和恢复的影响。在消失训练之前进行一次检索试验可以显著增强消失反应的更新和恢复。如果在不同的情境下进行检索和消失训练，则没有观察到恢复的增强。这些结果与Monfils和他的同事在老鼠身上以及Schiller和他的同事在人类身上发表的论文形成了对比。我们认为，这些截然不同的结果可能取决于以下两种截然不同的影响：(1)情境情境关联vs.由检索试验形成的直接情境cs关联；或(2)条件反射和消失情境之间的歧视vs.泛化。
In six experiments we studied the effects of a single re-exposure to a conditioned stimulus (CS; "retrieval trial") prior to extinction training (extinction-reconsolidation boundary) on the development of and recovery from fear extinction. A single retrieval trial prior to extinction training significantly augmented the renewal and reinstatement of extinguished responding. Augmentation of recovery was not observed if the retrieval and extinction training occurred in different contexts. These results contrast with those reported in earlier papers by Monfils and coworkers in rats and by Schiller and coworkers in humans. We suggest that these contrasting results could depend on the contrasting influences of either: (1) occasion-setting contextual associations vs. direct context-CS associations formed as a consequence of the retrieval trial or (2) discrimination vs. generalization between the circumstances of conditioning and extinction.