Scope of aminomethylations via Suzuki-Miyaura cross-coupling of organotrifluoroborates
Scope of aminomethylations via Suzuki-Miyaura cross-coupling of organotrifluoroborates
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DOI：
10.1021/jo800183q
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发表时间：
2008-03-21
影响因子：
3.6
通讯作者：
Sandrock, Deidre L.
中科院分区：
文献类型：
--
作者：
Molander, Gary A.;Gormisky, Paul E.;Sandrock, Deidre L.
我们以前报道过N，N-二烷氨基甲基三氟硼酸酯与芳基溴化物的Suzuki-Miyaura反应。在此，我们对钯催化的氨甲基化反应的范围和局限性进行了进一步的研究。芳基氯化物、碘化物和三氟化物以很好到很好的产率结合在一起，得到N，N-二烷基苄基胺。还考察了烯基溴化物的氨甲基化反应。
We previously reported the Suzuki-Miyaura reaction of N,N-dialkylaminomethyltrifluoroborates with aryl bromides. Herein, we report a further investigation of the scope and limitations of this palladium-catalyzed aminomethylation reaction. Aryl chlorides, iodides, and triflates coupled in good to excellent yields to give N,N-dialkylbenzylic amines. The aminomethylation of alkenyl bromides was also examined.