Temporal binding within and across events
Temporal binding within and across events
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DOI：
10.1016/j.nlm.2016.07.011
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发表时间：
2016-10-01
影响因子：
2.7
通讯作者：
Davachi, Lila
中科院分区：
文献类型：
--
作者：
DuBrow, Sarah;Davachi, Lila
记住事件发生的顺序是情景记忆的基本组成部分。然而，支持连续回忆的神经机制仍不清楚。从行为上来说，与跨事件边界相比，在同一事件中遇到的信息的连续回忆能力更强，这提高了上下文稳定性可能调节支持串行编码的认知和神经过程的可能性。在本研究中，我们在连续面部和物体刺激的编码过程中使用功能磁共振成像来阐明支持事件内和跨事件的后续连续回忆行为的神经编码特征。我们发现，中海马体和左腹外侧前额叶皮层 (PFC) 的单变量 BOLD 激活与随后对跨事件边界发生的项目的连续回忆相关。相比之下，事件中成功的串行编码与海马体和腹内侧 PFC 之间功能连接的增加有关，但与这些或其他区域的单变量激活无关。这些发现建立在暗示海马和 PFC 编码记忆时间方面过程的证据之上。他们进一步表明，这些编码过程受到结合是否发生在稳定的环境中或桥接两个相邻但不同的事件的影响。 (C) 2016 Elsevier Inc. 保留所有权利。
Remembering the order in which events occur is a fundamental component of episodic memory. However, the neural mechanisms supporting serial recall remain unclear. Behaviorally, serial recall is greater for information encountered within the same event compared to across event boundaries, raising the possibility that contextual stability may modulate the cognitive and neural processes supporting serial encoding. In the present study, we used fMRI during the encoding of consecutive face and object stimuli to elucidate the neural encoding signatures supporting subsequent serial recall behavior both within and across events. We found that univariate BOLD activation in both the middle hippocampus and left ventrolateral prefrontal cortex (PFC) was associated with subsequent serial recall of items that occur across event boundaries. By contrast, successful serial encoding within events was associated with increased functional connectivity between the hippocampus and ventromedial PFC, but not with univariate activation in these or other regions. These findings build on evidence implicating hippocampal and PFC processes in encoding temporal aspects of memory. They further suggest that these encoding processes are influenced by whether binding occurs within a stable context or bridges two adjacent but distinct events. (C) 2016 Elsevier Inc. All rights reserved.