Sex differences in extrastriatal dopamine D2-like receptors in the human brain
Sex differences in extrastriatal dopamine D2-like receptors in the human brain
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DOI：
10.1176/appi.ajp.158.2.308
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发表时间：
2001-02-01
影响因子：
17.7
通讯作者：
Rinne, JO
中科院分区：
文献类型：
--
作者：
Kaasinen, V;Någren, K;Rinne, JO
Objective: The study examined gender differences in extrastriatal dopamine D-2-like receptor levels in the human brain in vivo.Method: [C-11]FLB 457, a high-affinity radioligand for extrastriatal D-2-like receptors, and a three-dimensional positron emission tomography system were used to measure D-2-like receptor binding potentials in frontal cortex, temporal cortex, and thalamus in 12 healthy men and 12 healthy women.Results: Women had higher D-2-like receptor binding potentials than men in the three brain regions studied, and the difference in the frontal cortex was statistically significant. In a more detailed regional analysis, the difference between the sexes was most pronounced for the left and right anterior cingulate cortex.Conclusions: This study provides in vivo evidence for a gender difference in dopamine D-2-like receptor levels, which could be reflected in gender-associated differences in clinical disorders linked to the dopamine system.
