Dicarbonyl stress and glyoxalases in ovarian function.
Dicarbonyl stress and glyoxalases in ovarian function.
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DOI：
10.1042/bst20140023
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
C. Tatone;U. Eichenlaub-Ritter;F. Amicarelli
中科院分区：
文献类型：
--
作者：
C. Tatone;U. Eichenlaub-Ritter;F. Amicarelli
卵巢是女性生育力的主要调节器。母体健康和生理的变化会破坏卵巢内的稳态，从而损害卵母细胞的能力和生育能力。研究最近才注意到二羰基应激与卵巢功能的关系。在此基础上，本综述的重点是临床和实验研究支持的作用，二羰基超载和AGEs（晚期糖基化终产物）的卵巢微环境的扰动，导致生育力下降的关键因素。特别强调了卵母细胞对丙酮醛的敏感性，丙酮醛是一种强大的糖化剂，已知其水平在衰老和代谢紊乱期间会增加。根据文献，卵巢和卵母细胞本身可以依靠谷胱甘肽酶系统来抵消可能的二羰基过载，例如可能发生在育龄妇女和PCOS（多囊卵巢综合征）或糖尿病患者中的情况。总体而言，虽然需要建立适当的评价卵母细胞和卵巢微环境中的二羰基应激的生化方法，但AGEs可以作为改善生殖咨询和不孕症治疗的新策略中的预测标志物和/或治疗靶点。
The ovary is the main regulator of female fertility. Changes in maternal health and physiology can disrupt intraovarian homoeostasis thereby compromising oocyte competence and fertility. Research has only recently devoted attention to the involvement of dicarbonyl stress in ovarian function. On this basis, the present review focuses on clinical and experimental research supporting the role of dicarbonyl overload and AGEs (advanced glycation end-products) as key contributors to perturbations of the ovarian microenvironment leading to lower fertility. Particular emphasis has been given to oocyte susceptibility to methylglyoxal, a powerful glycating agent, whose levels are known to increase during aging and metabolic disorders. According to the literature, the ovary and the oocyte itself can rely on the glyoxalase system to counteract the possible dicarbonyl overload such as that which may occur in reproductive-age women and patients with PCOS (polycystic ovarian syndrome) or diabetes. Overall, although biochemical methods for proper evaluation of dicarbonyl stress in oocytes and the ovarian microenvironment need to be established, AGEs can be proposed as predictive markers and/or therapeutic targets in new strategies for improving reproductive counselling and infertility therapies.