HUMAN GASTRIC-EMPTYING AND COLONIC FILLING OF SOLIDS CHARACTERIZED BY A NEW METHOD
HUMAN GASTRIC-EMPTYING AND COLONIC FILLING OF SOLIDS CHARACTERIZED BY A NEW METHOD
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DOI：
10.1152/ajpgi.1989.257.2.g284
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发表时间：
1989-08-01
影响因子：
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通讯作者：
ZINSMEISTER, AR
中科院分区：
文献类型：
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作者：
CAMILLERI, M;COLEMONT, LJ;ZINSMEISTER, AR
我们的第一个目标是比较111In标记的Amberlite IR-12OP树脂小丸和131I标记的纤维在评估健康人的胃和小肠传输以及结肠充盈方面的作用。在体外胃模型中，这两种放射性标记在3小时内高度稳定，并且主要结合在5天内收集的粪便的固相上(90.5±-)。131I和87.4.+-的2.1%(SE)。111In为1.4%)。111In-微丸的胃排空延迟期较短(30。+-。11分钟，而58.+-。12min，131I-光纤，P<；0.05)。然而，~(111)I-颗粒和~(131)I-纤维的胃排空后相斜率和小肠半排出时间无显著差异。结肠充盈的特征是放射性标记的团注运动(范围10-80%，平均26%)，然后是平台(同位素不进入结肠的时间持续15-120分钟，平均51分钟)。一半的推注运动发生在第二顿饭摄入后1小时内。因此，111In标记的Amberlite微丸为研究人类的胃和小肠转运以及结肠充盈提供了一个很好的标记。回肠起到储存库的作用，通常在下一餐进食后不久，将大小不一的丸状物转移到结肠中。
Our first aim was to compare 111In-labeled Amberlite IR-12OP resin pellets and 131I-labeled fiber in the assessment of gastric and small bowel transit and colonic filling in healthy humans. Both radiolabels were highly stable for 3 h in an in vitro stomach model and remained predominantly bound to solid phase of stools collected over 5 days (90.5 .+-. 2.1 (SE)% for 131I and 87.4 .+-. 1.4% for 111In). The lag phase of gastric emptying was shorter for 111In-pellets (30 .+-. 11 min compared with 58 .+-. 12 min for 131I-fiber, P < 0.05). However, the slope of the postlag phase of gastric emptying and the half time of small bowel transit were not significantly different for 111I-pellets and 131I-fiber. Filling of the colon was characterized by bolus movements of the radiolabel (10-80% range, 26% mean) followed by plateaus (periods of no movement of isotope into colon lasting 15-120 min, range; 51 min, mean). Half of the bolus movements occurred within 1 h of the intake of a second meal. Thus 111In-labeled Amberlite pellets provide an excellent marker for the study of gastric and small bowel transit and colonic filling in humans. The ileum acts as a reservoir and transfers boluses of variable sizes into the colon, often soon after the intake of a subsequent meal.