Lamina depth and thickness correlate with glaucoma severity.
Lamina depth and thickness correlate with glaucoma severity.
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DOI：
10.4103/0301-4738.185594
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发表时间：
2016-05
影响因子：
3.1
通讯作者：
Chen PP
中科院分区：
文献类型：
--
作者：
Kim M;Bojikian KD;Slabaugh MA;Ding L;Chen PP
采用增强型深度成像光谱域光学相干断层扫描（SD-OCT）和Humphrey视野试验（HVF）评价原发性开角型青光眼（OAG）患者筛板（LC）形态与青光眼严重程度之间的相关性。OAG患者（n = 166），分为正常眼压性青光眼（NTG）和高眼压性青光眼（HTG）组（n = 66和n = 100），使用SD-OCT成像，以获得视神经乳头（ONH）的水平B扫描图像。在ONH中心测量层流深度（LD）和层流厚度（LT）。LD、LT和视野平均偏差（MD）的平均值（±标准差）分别为555.4 ± 142.3 μm、179.9 ± 49.7 μm和− 5.7 ± 6.4 dB。在多元线性回归分析中，LD、LT和眼压（IOP）与MD显著相关（分别为P = 0.007、P = 0.037和P = 0.004）。在亚组分析中，NTG组中仅LD与MD相关（n = 66），而HTG组中LT和IOP与MD相关（n = 100）。无论是眼轴长度，也没有中央角膜厚度与LD或LT。青光眼的严重程度，测量HVF MD，显示出显着的相关性与LD和LT，与更大的严重程度与增加LD和降低LT。正常和高张力OAG患者有不同的关联与LD和LT，这意味着这两个实体的发病机制可能是不同的。
To evaluate the correlation between lamina cribrosa (LC) morphology and glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) and Humphrey visual field test (HVF). Patients with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and laminar thickness (LT) were measured at the center of ONH. The mean (±standard deviation) values of LD, LT, and visual field mean deviation (MD) were 555.4 ± 142.3 μm, 179.9 ± 49.7 μm, and − 5.7 ± 6.4 dB, respectively. In the multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, respectively). In the subgroup analyses, only LD was associated with MD in the NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group (n = 100). Neither axial length nor central corneal thickness was associated with LD or LT. Glaucoma severity, as measured by HVF MD, shows significant correlations with LD and LT, with greater severity associated with increasing LD and decreasing LT. Normal- and high-tension OAG patients have different associations with LD and LT, which implies that the pathogenesis of these two entities might be different.