FMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
FMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families
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DOI：
10.1111/j.1530-0277.2007.00535.x
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发表时间：
2007-12-01
影响因子：
3.2
通讯作者：
Keshavan, Matcheri
中科院分区：
文献类型：
--
作者：
Hill, Shirley Y.;Kostelnik, Bryan;Keshavan, Matcheri
背景资料：酒精依赖（AD）的易感性增加可能与影响社会认知（更具体地说，心理理论（ToM））的大脑回路的结构和功能差异有关。酒精依赖者更有可能缺乏社交技能和更大的社会疏离感。这些特征可能与包括社会brain.Methods的神经解剖学网络的遗传差异有关：来自多发性AD家族和对照组的青少年/年轻成人参与者（n = 16）在性别、年龄、智商、教育和利手方面相匹配，并在功能磁共振成像（fMRI）期间执行Baron-Cohen的眼睛任务。与低风险对照组相比，高风险（HR）受试者的右侧颞中回（RMTG）和左侧额下回（LIFG）的血氧水平依赖性（BOLD）反应显著降低，而这两个区域以前与ToM任务有关。来自AD多重家族的后代可能表现出遗传易感性的一个方面，即在与ToM任务相关的大脑区域中具有减弱的BOLD反应。这些结果表明，那些有患AD风险的人可能对他人的精神状态感同身受的能力降低，可能导致社交技能下降。
Background: Increased susceptibility for developing alcohol dependence (AD) may be related to structural and functional differences in brain circuits that influence social cognition and more specifically, theory of mind (ToM). Alcohol dependent individuals have a greater likelihood of having deficits in social skills and greater social alienation. These characteristics may be related to inherited differences in the neuroanatomical network that comprises the social brain.Methods: Adolescent/young adult participants from multiplex AD families and controls (n = 16) were matched for gender, age, IQ, education, and handedness and administered the Eyes Task of Baron-Cohen during functional magnetic resonance imaging (fMRI).Results: High-risk (HR) subjects showed significantly diminished blood oxygen level dependent (BOLD) response in comparison with low-risk control young adults in the right middle temporal gyrus (RMTG) and the left inferior frontal gyrus (LIFG), areas that have previously been implicated in ToM tasks.Conclusions: Offspring from multiplex families for AD may manifest one aspect of their genetic susceptibility by having a diminished BOLD response in brain regions associated with performance of ToM tasks. These results suggest that those at risk for developing AD may have reduced ability to empathize with others' state of mind, possibly resulting in diminished social skill.