Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring
Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring
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DOI：
10.1016/s0014-4886(03)00272-3
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发表时间：
2003-11-01
影响因子：
5.3
通讯作者：
Xu, L
中科院分区：
文献类型：
--
作者：
Yang, YX;Ma, YM;Xu, L
临床和临床前研究的大量观察表明，发育中的大脑对铅(Pb2+)对S的有害影响特别敏感。然而，纯妊娠期铅暴露对成熟期认知功能的影响还没有研究。通过Morris水迷宫空间学习和固定位置/可见平台任务，研究了孕期低、中、高三种水平的铅暴露(0.03%、0.09%和0.27%的醋酸铅饲料)对幼年仔鼠空间记忆的潜在影响。结果表明，三种水平的铅暴露均显著损害雄性仔鼠的记忆提取，但只有低水平铅暴露的雌性子代才表现出记忆提取障碍。这些损害不是由于运动能力和视觉的严重干扰，因为这些动物执行固定位置/可见平台任务和对照，这表明空间学习/记忆的特定方面受到了损害。这些结果表明，在妊娠期接触铅足以导致年轻成年后代的长期学习/记忆障碍。(C)2003 Elsevier Inc.保留所有权利。
Numerous observations in clinical and preclinical studies indicate that the developing brain is particular sensitive to lead (Pb)'s pernicious effects. However, the effect of gestation-only Pb exposure on cognitive functions at maturation has not been studied. We investigated the potential effects of three levels of Pb exposure (low, middle, and high Pb: 0.03%, 0.09%, and 0.27% of lead acetate-containing diets) at the gestational period on the spatial memory of young adult offspring by Morris water maze spatial learning and fixed location/visible platform tasks. Our results revealed that three levels of Pb exposure significantly impaired memory retrieval in male offspring, but only female offspring at low levels of Pb exposure showed impairment of memory retrieval. These impairments were not due to the gross disturbances in motor performance and in vision because these animals performed the fixed location/visible platform task as well as controls, indicating that the specific aspects of spatial learning/memory were impaired. These results suggest that exposure to Pb during the gestational period is sufficient to cause long-term learning/memory deficits in young adult offspring. (C) 2003 Elsevier Inc. All rights reserved.