Methyl 2-((succinimidooxy)carbonyl)benzoate (MSB):: A new, efficient reagent for N-phthaloylation of amino acid and peptide derivatives
Methyl 2-((succinimidooxy)carbonyl)benzoate (MSB):: A new, efficient reagent for N-phthaloylation of amino acid and peptide derivatives
复制标题
DOI：
10.1021/jo016347h
复制
发表时间：
2002-05-31
影响因子：
3.6
通讯作者：
Briand, JP
中科院分区：
文献类型：
--
作者：
Casimir, JR;Guichard, G;Briand, JP
介绍了一种新的、高效的、易得的氨基酸及其衍生物的N-邻苯二甲酰化试剂2-（（琥珀酰亚胺氧基）羰基）苯甲酸甲酯（MSB）。邻苯二甲酰化过程简单且无外消旋化，并且对于α-氨基酸、α-氨基醇、二肽、α-氨基甲酰胺和α-氨基酯给出优异的结果。
A new, efficient, and readily available reagent, methyl 2-((succinimidooxy)carbonyl)benzoate (MSB), for N-phthaloylation of amino acids and amino acid derivatives is described. The phthaloylation procedure is simple and racemization-free and gives excellent results with a-amino acids, a-amino alcohols, dipeptides, alpha-amino carboxamides, and alpha-amino esters.