Antifungal action of rifampin.
Antifungal action of rifampin.
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利福平的抗真菌作用。
DOI：
10.1093/clinids/5.supplement_3.s614
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Medoff,G
中科院分区：
文献类型：
--
作者：
Medoff,G
利福平和两性霉素B在体外对酿酒酵母、组织胞浆菌和几种曲霉菌有协同作用，两性霉素B使真菌对利福平的摄取增加，这可能是观察到协同作用的基础。在体内，事实证明，联合用药比任何一种药物单独治疗实验性感染都更有效。囊状芽孢杆菌、皮炎芽孢杆菌和曲霉菌。
Rifampin and amphotericin B were found to be synergistic in vitro againstSaccharomyces cerevisiae,Histoplasma capsulatum, and several species ofAspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed. In vivo, the combination proved more effective than either drug alone against experimental infections withH. capsulatum,Blastomyces dermatitidis, andAspergillusspecies.