Pharmacological dissociation between the reinforcing, sensitizing, and response-releasing functions of reward in honeybee classical conditioning
Pharmacological dissociation between the reinforcing, sensitizing, and response-releasing functions of reward in honeybee classical conditioning
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DOI：
10.1037/0735-7044.113.4.744
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发表时间：
1999-08-01
影响因子：
1.9
通讯作者：
Fiala, A
中科院分区：
文献类型：
--
作者：
Menzel, R;Heyne, A;Fiala, A
利血平消耗生物胺从他们的商店在蜜蜂（蜜蜂carnica）的大脑，并导致受损的食欲调节使用蔗糖作为甜味剂。将章鱼胺或多巴胺直接注射到大脑中可以恢复这些行为损失。多巴胺挽救了对运动模式的减慢效应，但不是敏化或条件反射。章鱼胺使运动模式和致敏作用保持不变，但挽救了条件反射。特别是章鱼胺拯救收购，但没有检索。5-羟色胺对致敏作用无显著影响，但会损害条件反射。作者得出结论，章鱼胺参与选择性介导蔗糖奖励的强化功能，而不是敏化或反应释放功能，而多巴胺则选择性参与运动反应的表达。
Reserpine depletes biogenic amines from their stores in the honeybee (Apis mellifera carnica) brain and leads to impaired appetitive conditioning using sucrose as a reinforcer. Compensatory injection of octopamine or dopamine directly into the brain restores these behavioral losses. Dopamine rescues the slowing-down effect on motor patterns, but not sensitization or conditioning. Octopamine leaves the motor patterns as well as sensitization unchanged but rescues conditioning. Specifically octopamine rescues acquisition but not retrieval. Serotonin has no significant effect: on sensitization but impairs conditioning. The authors conclude that octopamine is involved in selectively mediating the reinforcing but not the sensitizing or response-releasing function of the sucrose reward, whereas dopamine is selectively involved in the expression of the motor response.