ARE ANTAGONISTS OF DOPAMINE-D1 RECEPTORS DRUGS THAT ATTENUATE BOTH POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA - A PILOT-STUDY IN JAVA MONKEYS
ARE ANTAGONISTS OF DOPAMINE-D1 RECEPTORS DRUGS THAT ATTENUATE BOTH POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA - A PILOT-STUDY IN JAVA MONKEYS
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DOI：
10.1016/0893-133x(89)90022-5
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发表时间：
1989-09-01
影响因子：
7.6
通讯作者：
COOLS, AR
中科院分区：
文献类型：
--
作者：
ELLENBROEK, BA;WILLEMEN, APM;COOLS, AR
众所周知，安非他明会引起不同物种的刻板行为。长期以来，这种效应被认为是精神分裂症阳性症状的动物模型。此外，已知安非他明会导致社交生活的猴子产生强烈的社会孤立感。从症状学和药理学角度来看，这种由安非他明引起的社会隔离被认为代表了精神分裂症阴性症状的动物模型。迄今为止，尚未找到针对这些阴性症状的有效治疗方法。我们现在报道，选择性 D1 多巴胺拮抗剂 SCH 23390 在拮抗安非他明引起的爪哇猴的刻板行为和社会孤立方面非常有效。此外，SCH 23390 能够恢复这些动物的正常行为。这些结果可能对我们理解 D1 受体的功能意义以及精神分裂症阳性和阴性症状的临床治疗产生重要影响。
Amphetamine is known to elicit stereotyped behavior in various species. For a long time, this effect was considered to be an animal model for the positive symptoms of schizophrenia. In addition, amphetamine is known to induce a strong social isolation in socially living monkeys. Both on symptomatologic and pharmacologic grounds, this amphetamine-induced social isolation has been suggested to represent an animal model for the negative symptoms of schizophrenia. To date no effective treatment has been found for these negative symptoms. We now report that the selective D1 dopamine antagonist SCH 23390 is very effective in antagonizing both the stereotyped behavior and the social isolation in Java monkeys induced by amphetamine. Moreover, SCH 23390 is able to reinstate normal behavior in these animals. These results may have important consequences for our understanding of the functional significance of the D1 receptor as well as for the clinical treatment of the positive and negative symptoms of schizophrenia.