3'-Daidzein sulfonate sodium improves mitochondrial functions after cerebral ischemia/reperfusion injury.
3'-Daidzein sulfonate sodium improves mitochondrial functions after cerebral ischemia/reperfusion injury.
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DOI：
10.4103/1673-5374.200807
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发表时间：
2017-02
影响因子：
6.1
通讯作者：
Lei Q
中科院分区：
文献类型：
--
作者：
Yuan W;Chen Q;Zeng J;Xiao H;Huang ZH;Li X;Lei Q
3′-大豆苷元磺酸钠是由葛根中的活性成分大豆苷元合成的一种新的水溶性化合物。它已被证明对大鼠脑缺血/再灌注损伤具有保护作用。我们计划研究其保护作用的机制。脑缺血再灌注损伤后，注射3′-大豆苷元磺酸钠。结果表明，3′-大豆苷元磺酸钠能显著降低线粒体肿胀，显著升高线粒体膜电位，提高线粒体超氧化物歧化酶和谷胱甘肽过氧化物酶活性，降低线粒体丙二醛水平。3′-大豆苷元磺酸钠能改善血脑屏障的结构完整性，降低血脑屏障通透性。这些结果证实3′-大豆苷元磺酸钠对脑缺血再灌注损伤后线粒体功能具有保护作用，改善脑能量代谢，对血脑屏障损伤具有保护作用。
3′-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein (an active ingredient of the kudzu vine root). It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3′-Daidzein sulfonate sodium was injected in rats after cerebral ischemia/reperfusion injury. Results showed that 3′-daidzein sulfonate sodium significantly reduced mitochondrial swelling, significantly elevated the mitochondrial membrane potential, increased mitochondrial superoxide dismutase and glutathione peroxidase activities, and decreased mitochondrial malondialdehyde levels. 3′-Daidzein sulfonate sodium improved the structural integrity of the blood-brain barrier and reduced blood-brain barrier permeability. These findings confirmed that 3′-daidzein sulfonate sodium has a protective effect on mitochondrial functions after cerebral ischemia/reperfusion injury, improves brain energy metabolism, and provides protection against blood-brain barrier damage.