Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles.
Cross-sex hormone treatment and own-body perception: behavioral and brain connectivity profiles.
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DOI：
10.1038/s41598-020-80687-2
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发表时间：
2021-02-02
影响因子：
4.6
通讯作者：
Savic I
中科院分区：
文献类型：
--
作者：
Khorashad BS;Manzouri A;Feusner JD;Savic I
性别焦虑症（GD）的特征是性别认同和出生时指定性别之间令人痛苦的不一致，这种情况正在稳步增加。潜在的神经生物学和通常有益的跨性别激素治疗的机制尚不清楚。在这里，我们测试的假设，自己的身体感知网络（纳入默认模式网络DMN，部分在显着性网络SN），是不同的反式相比，顺式性别的人。我们还调查了这些网络是否会随着跨性别激素治疗而改变。对40例跨性别男性（TrM）和25例跨性别女性（TrW）在跨性别激素治疗前后进行了扫描。我们使用我们自己开发的身体形态测试（BM），以评估自己的身体作为自我的感知。15名顺性别者为对照组。使用DMN、SN和运动网络（控制网络）内的独立成分分析计算功能连接的组内和组间差异。治疗前，TrM和TrW在BM测试中的“自我”得分低于对照组。他们在扣带回前部、内侧前额叶皮质、楔前叶、左侧角回和DMN的上级顶叶皮质的功能连接较弱，在SN“自我”识别中的ACC和TrM和TrW中的mPFC的连接从扫描1到扫描2增加，并且在扫描2时没有组间差异。构成DMN主要部分的大脑结构似乎有助于GD的神经生物学基础。
Referrals for gender dysphoria (GD), characterized by a distressful incongruence between gender identity and at-birth assigned sex, are steadily increasing. The underlying neurobiology, and the mechanisms of the often-beneficial cross-sex hormone treatment are unknown. Here, we test hypothesis that own body perception networks (incorporated in the default mode network—DMN, and partly in the salience network—SN), are different in trans-compared with cis-gender persons. We also investigate whether these networks change with cross-sex hormone treatment. Forty transmen (TrM) and 25 transwomen (TrW) were scanned before and after cross-sex hormone institution. We used our own developed Body Morph test (BM), to assess the perception of own body as self. Fifteen cisgender persons were controls. Within and between-group differences in functional connectivity were calculated using independent components analysis within the DMN, SN, and motor network (a control network). Pretreatment, TrM and TrW scored lower “self” on the BM test than controls. Their functional connections were weaker in the anterior cingulate-, mesial prefrontal-cortex (mPFC), precuneus, the left angular gyrus, and superior parietal cortex of the DMN, and ACC in the SN “Self” identification and connectivity in the mPFC in both TrM and TrW increased from scan 1 to 2, and at scan 2 no group differences remained. The neurobiological underpinnings of GD seem subserved by cerebral structures composing major parts of the DMN.